tetano
Editor, Senior Moderator
Cell Rep
. 2022 Dec 13;41(11):111828.
doi: 10.1016/j.celrep.2022.111828.
Alveolar macrophages instruct CD8[SUP]+[/SUP] T cell expansion by antigen cross-presentation in lung
Takumi Kawasaki[SUP] 1 [/SUP], Moe Ikegawa[SUP] 2 [/SUP], Kosuke Yunoki[SUP] 2 [/SUP], Hifumi Otani[SUP] 2 [/SUP], Daisuke Ori[SUP] 2 [/SUP], Ken J Ishii[SUP] 3 [/SUP], Etsushi Kuroda[SUP] 4 [/SUP], Shiki Takamura[SUP] 5 [/SUP], Masahiro Kitabatake[SUP] 6 [/SUP], Toshihiro Ito[SUP] 6 [/SUP], Ayako Isotani[SUP] 7 [/SUP], Taro Kawai[SUP] 8 [/SUP]
Affiliations
Abstract
Lung CD8[SUP]+[/SUP] memory T cells play central roles in protective immunity to respiratory viruses, such as influenza A virus (IAV). Here, we find that alveolar macrophages (AMs) function as antigen-presenting cells that support the expansion of lung CD8[SUP]+[/SUP] memory T cells. Intranasal antigen administration to mice subcutaneously immunized with antigen results in a rapid expansion of antigen-specific CD8[SUP]+[/SUP] T cells in the lung, which is dependent on antigen cross-presentation by AMs. AMs highly express interleukin-18 (IL-18), which mediates subsequent formation of CD103[SUP]+[/SUP]CD8[SUP]+[/SUP] resident memory T (T[SUB]RM[/SUB]) cells in the lung. In a mouse model of IAV infection, AMs are required for expansion of virus-specific CD8[SUP]+[/SUP] T cells and CD103[SUP]+[/SUP]CD8[SUP]+[/SUP] T[SUB]RM[/SUB] cells and inhibiting virus replication in the lungs during secondary infection. These results suggest that AMs instruct a rapid expansion of antigen-specific CD8[SUP]+[/SUP] T cells in lung, which protect the host from respiratory virus infection.
Keywords: CP: Immunology; IL-18; alveolar macrophage; antigen presentation; cross-presentation; dendritic cell; influenza A virus; resident memory CD8(+) T cell.
. 2022 Dec 13;41(11):111828.
doi: 10.1016/j.celrep.2022.111828.
Alveolar macrophages instruct CD8[SUP]+[/SUP] T cell expansion by antigen cross-presentation in lung
Takumi Kawasaki[SUP] 1 [/SUP], Moe Ikegawa[SUP] 2 [/SUP], Kosuke Yunoki[SUP] 2 [/SUP], Hifumi Otani[SUP] 2 [/SUP], Daisuke Ori[SUP] 2 [/SUP], Ken J Ishii[SUP] 3 [/SUP], Etsushi Kuroda[SUP] 4 [/SUP], Shiki Takamura[SUP] 5 [/SUP], Masahiro Kitabatake[SUP] 6 [/SUP], Toshihiro Ito[SUP] 6 [/SUP], Ayako Isotani[SUP] 7 [/SUP], Taro Kawai[SUP] 8 [/SUP]
Affiliations
- PMID: 36516765
- DOI: 10.1016/j.celrep.2022.111828
Abstract
Lung CD8[SUP]+[/SUP] memory T cells play central roles in protective immunity to respiratory viruses, such as influenza A virus (IAV). Here, we find that alveolar macrophages (AMs) function as antigen-presenting cells that support the expansion of lung CD8[SUP]+[/SUP] memory T cells. Intranasal antigen administration to mice subcutaneously immunized with antigen results in a rapid expansion of antigen-specific CD8[SUP]+[/SUP] T cells in the lung, which is dependent on antigen cross-presentation by AMs. AMs highly express interleukin-18 (IL-18), which mediates subsequent formation of CD103[SUP]+[/SUP]CD8[SUP]+[/SUP] resident memory T (T[SUB]RM[/SUB]) cells in the lung. In a mouse model of IAV infection, AMs are required for expansion of virus-specific CD8[SUP]+[/SUP] T cells and CD103[SUP]+[/SUP]CD8[SUP]+[/SUP] T[SUB]RM[/SUB] cells and inhibiting virus replication in the lungs during secondary infection. These results suggest that AMs instruct a rapid expansion of antigen-specific CD8[SUP]+[/SUP] T cells in lung, which protect the host from respiratory virus infection.
Keywords: CP: Immunology; IL-18; alveolar macrophage; antigen presentation; cross-presentation; dendritic cell; influenza A virus; resident memory CD8(+) T cell.