tetano
Editor, Senior Moderator
Cell Rep Med
. 2022 Jan 19;3(2):100520.
doi: 10.1016/j.xcrm.2022.100520. eCollection 2022 Feb 15.
Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8 [SUP]+[/SUP] T cell responses
Hiroshi Ishii[SUP] 1 [/SUP], Takushi Nomura[SUP] 1 [/SUP], Hiroyuki Yamamoto[SUP] 1 [/SUP], Masako Nishizawa[SUP] 1 [/SUP], Trang Thi Thu Hau[SUP] 1 [/SUP], Shigeyoshi Harada[SUP] 1 [/SUP], Sayuri Seki[SUP] 1 [/SUP], Midori Nakamura-Hoshi[SUP] 1 [/SUP], Midori Okazaki[SUP] 1 [/SUP], Sachie Daigen[SUP] 1 [/SUP], Ai Kawana-Tachikawa[SUP] 1 2 3 [/SUP], Noriyo Nagata[SUP] 4 [/SUP], Naoko Iwata-Yoshikawa[SUP] 4 [/SUP], Nozomi Shiwa[SUP] 4 [/SUP], Tadaki Suzuki[SUP] 4 [/SUP], Eun-Sil Park[SUP] 5 [/SUP], Maeda Ken[SUP] 5 [/SUP], Taishi Onodera[SUP] 6 [/SUP], Yoshimasa Takahashi[SUP] 6 [/SUP], Kohji Kusano[SUP] 7 [/SUP], Ryutaro Shimazaki[SUP] 7 [/SUP], Yuriko Suzaki[SUP] 8 [/SUP], Yasushi Ami[SUP] 8 [/SUP], Tetsuro Matano[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Effective vaccines are essential for the control of the coronavirus disease 2019 (COVID-19) pandemic. Currently developed vaccines inducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-antigen-specific neutralizing antibodies (NAbs) are effective, but the appearance of NAb-resistant S variant viruses is of great concern. A vaccine inducing S-independent or NAb-independent SARS-CoV-2 control may contribute to containment of these variants. Here, we investigate the efficacy of an intranasal vaccine expressing viral non-S antigens against intranasal SARS-CoV-2 challenge in cynomolgus macaques. Seven vaccinated macaques exhibit significantly reduced viral load in nasopharyngeal swabs on day 2 post-challenge compared with nine unvaccinated controls. The viral control in the absence of SARS-CoV-2-specific NAbs is significantly correlated with vaccine-induced, viral-antigen-specific CD8[SUP]+[/SUP] T cell responses. Our results indicate that CD8[SUP]+[/SUP] T cell induction by intranasal vaccination can result in NAb-independent control of SARS-CoV-2 infection, highlighting a potential of vaccine-induced CD8[SUP]+[/SUP] T cell responses to contribute to COVID-19 containment.
Keywords: CD8+ T cell; COVID-19; intranasal; vaccine; variant; viral vector.
. 2022 Jan 19;3(2):100520.
doi: 10.1016/j.xcrm.2022.100520. eCollection 2022 Feb 15.
Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8 [SUP]+[/SUP] T cell responses
Hiroshi Ishii[SUP] 1 [/SUP], Takushi Nomura[SUP] 1 [/SUP], Hiroyuki Yamamoto[SUP] 1 [/SUP], Masako Nishizawa[SUP] 1 [/SUP], Trang Thi Thu Hau[SUP] 1 [/SUP], Shigeyoshi Harada[SUP] 1 [/SUP], Sayuri Seki[SUP] 1 [/SUP], Midori Nakamura-Hoshi[SUP] 1 [/SUP], Midori Okazaki[SUP] 1 [/SUP], Sachie Daigen[SUP] 1 [/SUP], Ai Kawana-Tachikawa[SUP] 1 2 3 [/SUP], Noriyo Nagata[SUP] 4 [/SUP], Naoko Iwata-Yoshikawa[SUP] 4 [/SUP], Nozomi Shiwa[SUP] 4 [/SUP], Tadaki Suzuki[SUP] 4 [/SUP], Eun-Sil Park[SUP] 5 [/SUP], Maeda Ken[SUP] 5 [/SUP], Taishi Onodera[SUP] 6 [/SUP], Yoshimasa Takahashi[SUP] 6 [/SUP], Kohji Kusano[SUP] 7 [/SUP], Ryutaro Shimazaki[SUP] 7 [/SUP], Yuriko Suzaki[SUP] 8 [/SUP], Yasushi Ami[SUP] 8 [/SUP], Tetsuro Matano[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 35233545
- PMCID: PMC8768424
- DOI: 10.1016/j.xcrm.2022.100520
Abstract
Effective vaccines are essential for the control of the coronavirus disease 2019 (COVID-19) pandemic. Currently developed vaccines inducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-antigen-specific neutralizing antibodies (NAbs) are effective, but the appearance of NAb-resistant S variant viruses is of great concern. A vaccine inducing S-independent or NAb-independent SARS-CoV-2 control may contribute to containment of these variants. Here, we investigate the efficacy of an intranasal vaccine expressing viral non-S antigens against intranasal SARS-CoV-2 challenge in cynomolgus macaques. Seven vaccinated macaques exhibit significantly reduced viral load in nasopharyngeal swabs on day 2 post-challenge compared with nine unvaccinated controls. The viral control in the absence of SARS-CoV-2-specific NAbs is significantly correlated with vaccine-induced, viral-antigen-specific CD8[SUP]+[/SUP] T cell responses. Our results indicate that CD8[SUP]+[/SUP] T cell induction by intranasal vaccination can result in NAb-independent control of SARS-CoV-2 infection, highlighting a potential of vaccine-induced CD8[SUP]+[/SUP] T cell responses to contribute to COVID-19 containment.
Keywords: CD8+ T cell; COVID-19; intranasal; vaccine; variant; viral vector.