tetano
Editor, Senior Moderator
Cell Stress Chaperones
. 2020 Jul 29.
doi: 10.1007/s12192-020-01145-6. Online ahead of print.
SARS-CoV-2 and Guillain-Barr? syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism
Guglielmo Lucchese[SUP] 1 [/SUP], Agnes Fl?el[SUP] 2 3 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barr? syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barr? syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
Keywords: COVID-19; Demyelination; Neuropathy.
. 2020 Jul 29.
doi: 10.1007/s12192-020-01145-6. Online ahead of print.
SARS-CoV-2 and Guillain-Barr? syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism
Guglielmo Lucchese[SUP] 1 [/SUP], Agnes Fl?el[SUP] 2 3 [/SUP]
Affiliations
- PMID: 32729001
- DOI: 10.1007/s12192-020-01145-6
Abstract
Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barr? syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barr? syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
Keywords: COVID-19; Demyelination; Neuropathy.