tetano
Editor, Senior Moderator
Cells
. 2022 Apr 26;11(9):1458.
doi: 10.3390/cells11091458.
SARS-CoV-2 Attacks in the Brain: Focus on the Sialome
Przemyslaw Wielgat[SUP] 1 [/SUP], Karolina Narejko[SUP] 1 [/SUP], Halina Car[SUP] 1 2 [/SUP]
Affiliations
Abstract
The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that the neuroinvasive potential of SARS-CoV-2 is closely related to its capacity to interact with cell membrane sialome. Given the wide expression of sialylated compounds of cell membranes in the brain, the interplay between cell membrane sialoglycans and the virus is crucial for its attachment and cell entry, transport, neuronal damage and brain immunity. Here, we focus on the significance of the brain sialome in the progress of coronavirus disease 2019 (COVID-19) and SARS-CoV-2-induced neuropathology.
Keywords: COVID-19; SARS-CoV-2; brain; inflammation; neurons; sialic acid.
. 2022 Apr 26;11(9):1458.
doi: 10.3390/cells11091458.
SARS-CoV-2 Attacks in the Brain: Focus on the Sialome
Przemyslaw Wielgat[SUP] 1 [/SUP], Karolina Narejko[SUP] 1 [/SUP], Halina Car[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35563764
- DOI: 10.3390/cells11091458
Abstract
The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that the neuroinvasive potential of SARS-CoV-2 is closely related to its capacity to interact with cell membrane sialome. Given the wide expression of sialylated compounds of cell membranes in the brain, the interplay between cell membrane sialoglycans and the virus is crucial for its attachment and cell entry, transport, neuronal damage and brain immunity. Here, we focus on the significance of the brain sialome in the progress of coronavirus disease 2019 (COVID-19) and SARS-CoV-2-induced neuropathology.
Keywords: COVID-19; SARS-CoV-2; brain; inflammation; neurons; sialic acid.
