Mary Wilson
Well-known member
Published: 24 May 2023
https://doi.org/10.1093/infdis/jiad178
Mikihiro Yunoki, Ritsuko Kubota-Koketsu, Teruaki Imada, Kazuhiro Furuyama, Takahiro Sasaki, Shinichi Ohashi, Tatsuo Shioda
Abstract
The anti-spike (S), anti-nucleocapsid (N), and neutralizing activities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of pooled plasma derived from donors in Japan from January 2021 to April 2022 were evaluated. Anti-S titers and neutralizing activities showed a wave-like trend affected by daily vaccinations and/or the number of reported cases of SARS-CoV-2 infections, whereas anti-N titers remained at negative levels. These results suggest that anti-S and neutralizing titers would fluctuate in pooled plasma in future. Pooled plasma may be potentially used for mass-immunity evaluation, and titer estimation in intravenous immunoglobulin, a derivative of pooled plasma.
https://watermark.silverchair.com/j...mtauGGvgVTaKYKcrSnIH-D_PbiGPfG9W7NzryIE3i35vg
https://doi.org/10.1093/infdis/jiad178
Mikihiro Yunoki, Ritsuko Kubota-Koketsu, Teruaki Imada, Kazuhiro Furuyama, Takahiro Sasaki, Shinichi Ohashi, Tatsuo Shioda
Abstract
The anti-spike (S), anti-nucleocapsid (N), and neutralizing activities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of pooled plasma derived from donors in Japan from January 2021 to April 2022 were evaluated. Anti-S titers and neutralizing activities showed a wave-like trend affected by daily vaccinations and/or the number of reported cases of SARS-CoV-2 infections, whereas anti-N titers remained at negative levels. These results suggest that anti-S and neutralizing titers would fluctuate in pooled plasma in future. Pooled plasma may be potentially used for mass-immunity evaluation, and titer estimation in intravenous immunoglobulin, a derivative of pooled plasma.
https://watermark.silverchair.com/j...mtauGGvgVTaKYKcrSnIH-D_PbiGPfG9W7NzryIE3i35vg