Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight

[tetano]

J Vet Med Sci. 2019 Jan 24. doi: 10.1292/jvms.18-0628. [Epub ahead of print]
[h=1]Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight to Japan.[/h] Shibata A[SUP]1[/SUP], Harada R[SUP]1[/SUP], Okamatsu M[SUP]2[/SUP], Matsuno K[SUP]2,[/SUP][SUP]3[/SUP], Arita T[SUP]4[/SUP], Suzuki Y[SUP]4[/SUP], Shirakura M[SUP]4[/SUP], Odagiri T[SUP]4[/SUP], Takemae N[SUP]5[/SUP], Uchida Y[SUP]5[/SUP], Saito T[SUP]5[/SUP], Sakoda Y[SUP]2,[/SUP][SUP]3[/SUP], Osaka H[SUP]1[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] A new reassortant H7N3 avian influenza virus (AIV) was isolated from a duck meat product that was illegally taken on board a passenger flight from China to Japan in March 2018. Sequencing analysis revealed that the H7N3 isolate, A/duck/Japan/AQ-HE30-1/2018 (Dk/HE30-1) (H7N3), was a reassortant highly pathogenic avian influenza virus (HPAIV) that contained the haemagglutinin (HA) gene of Chinese H7N9 HPAIV. Dk/HE30-1 (H7N3) possessed a novel polybasic sequence motif PEVPKRRRTAR/GLF at the HA cleavage site that has never previously been reported in H7 HPAIVs. The HA antigenicity of Dk/HE30-1 (H7N3) slightly differed from that of H7N9 HPAIVs previously reported. These findings will help further our knowledge of the circulation and genetic evolution of emerging AIVs in endemic areas.


[h=4]KEYWORDS:[/h] H7N3 subtype; highly pathogenic avian influenza virus; reassortant virus

PMID: 30674734 DOI: 10.1292/jvms.18-0628







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