tetano
Editor, Senior Moderator
Virology. 2012 Aug 23. [Epub ahead of print]
Characterization of an influenza A virus in Mexican swine that is related to the A/H1N1/2009 pandemic clade.
Escalera-Zamudio M, Cobi?n-G?emes G, de Los Dolores Soto-Del R?o M, Isa P, S?nchez-Betancourt I, Parissi-Crivelli A, Teresa Mart?nez-C?zares M, Romero P, Vel?zquez-Salinas L, Huerta-Lozano B, Nelson M, Montero H, Vinuesa P, L?pez S, Arias CF.
Source
Instituto de Biotecnolog?a, Universidad Nacional Aut?noma de M?xico, Cuernavaca, Morelos, Mexico.
Abstract
In the spring of 2009, swine-origin influenza H1N1pdm09 viruses caused the first influenza pandemic of this century. We characterized the influenza viruses that circulated early during the outbreak in Mexico, including one newly sequenced swine H1N1pdm09 virus and three newly sequenced human H1N1pdm09 viruses that circulated in the outbreak of respiratory disease in La Gloria, Veracruz. Phylogenetic analysis revealed that the swine isolate (A/swine/Mexico/4/2009) collected in April 2009 is positioned in a branch that is basal to the rest of the H1N1pdm09 clade in two (NP and PA) of the eight single-gene trees. In addition, the concatenated HA-NA and the complete whole-genome trees also showed a basal position for A/swine/Mexico/4/2009. Furthermore, this swine virus was found to share molecular traits with non-H1N1pdm09 H1N1 viral lineages. These results suggest that this isolate could potentially be the first one detected from a sister lineage closely related to the H1N1pdm09 viruses.
Copyright ? 2012 Elsevier Inc. All rights reserved.
PMID:
22921315
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22921315
Characterization of an influenza A virus in Mexican swine that is related to the A/H1N1/2009 pandemic clade.
Escalera-Zamudio M, Cobi?n-G?emes G, de Los Dolores Soto-Del R?o M, Isa P, S?nchez-Betancourt I, Parissi-Crivelli A, Teresa Mart?nez-C?zares M, Romero P, Vel?zquez-Salinas L, Huerta-Lozano B, Nelson M, Montero H, Vinuesa P, L?pez S, Arias CF.
Source
Instituto de Biotecnolog?a, Universidad Nacional Aut?noma de M?xico, Cuernavaca, Morelos, Mexico.
Abstract
In the spring of 2009, swine-origin influenza H1N1pdm09 viruses caused the first influenza pandemic of this century. We characterized the influenza viruses that circulated early during the outbreak in Mexico, including one newly sequenced swine H1N1pdm09 virus and three newly sequenced human H1N1pdm09 viruses that circulated in the outbreak of respiratory disease in La Gloria, Veracruz. Phylogenetic analysis revealed that the swine isolate (A/swine/Mexico/4/2009) collected in April 2009 is positioned in a branch that is basal to the rest of the H1N1pdm09 clade in two (NP and PA) of the eight single-gene trees. In addition, the concatenated HA-NA and the complete whole-genome trees also showed a basal position for A/swine/Mexico/4/2009. Furthermore, this swine virus was found to share molecular traits with non-H1N1pdm09 H1N1 viral lineages. These results suggest that this isolate could potentially be the first one detected from a sister lineage closely related to the H1N1pdm09 viruses.
Copyright ? 2012 Elsevier Inc. All rights reserved.
PMID:
22921315
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22921315