tetano
Editor, Senior Moderator
Vet Microbiol. 2017 Mar;201:225-230. doi: 10.1016/j.vetmic.2017.01.028. Epub 2017 Jan 24.
[h=1]Characterization of H5N1 highly pathogenic mink influenza viruses in eastern China.[/h] Jiang W[SUP]1[/SUP], Wang S[SUP]2[/SUP], Zhang C[SUP]3[/SUP], Li J[SUP]2[/SUP], Hou G[SUP]2[/SUP], Peng C[SUP]2[/SUP], Chen J[SUP]2[/SUP], Shan H[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Members of the H5 subtype of highly pathogenic avian influenza viruses pose a great threat to both poultry and humans with severe consequences for both industry and public health sectors. Here, we isolated and characterized two H5N1 highly pathogenic influenza viruses in deceased mink from eastern China. Phylogenetic analyses showed that the G15 and XB15 viruses belonged to clade 2.3.2.1b and 2.3.2.1e, respectively. Both of these viruses were highly pathogenic in chickens. They were also shown to exhibit moderate to high pathogenicity in mice without pre-adaptation. Further, the mink influenza viruses had severe antigenic drift with corresponding Re-6 vaccine and current vaccines may fail to confer protection against these H5N1 viruses in poultry.
Copyright ? 2017 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Antigenicity; H5N1; Mink; Pathogenicity
PMID: 28284614 DOI: 10.1016/j.vetmic.2017.01.028
[h=1]Characterization of H5N1 highly pathogenic mink influenza viruses in eastern China.[/h] Jiang W[SUP]1[/SUP], Wang S[SUP]2[/SUP], Zhang C[SUP]3[/SUP], Li J[SUP]2[/SUP], Hou G[SUP]2[/SUP], Peng C[SUP]2[/SUP], Chen J[SUP]2[/SUP], Shan H[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Members of the H5 subtype of highly pathogenic avian influenza viruses pose a great threat to both poultry and humans with severe consequences for both industry and public health sectors. Here, we isolated and characterized two H5N1 highly pathogenic influenza viruses in deceased mink from eastern China. Phylogenetic analyses showed that the G15 and XB15 viruses belonged to clade 2.3.2.1b and 2.3.2.1e, respectively. Both of these viruses were highly pathogenic in chickens. They were also shown to exhibit moderate to high pathogenicity in mice without pre-adaptation. Further, the mink influenza viruses had severe antigenic drift with corresponding Re-6 vaccine and current vaccines may fail to confer protection against these H5N1 viruses in poultry.
Copyright ? 2017 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Antigenicity; H5N1; Mink; Pathogenicity
PMID: 28284614 DOI: 10.1016/j.vetmic.2017.01.028