tetano
Editor, Senior Moderator
J Pharmacol Sci. 2014 Oct 9. [Epub ahead of print]
Characterization of Susceptibility Variants of Influenza Virus Grown in the Presence of T-705.
Daikoku T1, Yoshida Y, Okuda T, Shiraki K.
Author information
Abstract
T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strain had amino acid variations in the PB1, PB2, and PA genes of the RNA polymerase complex. However, the variation patterns in the RNA polymerase complex indicated that T-705 does not work as a mutagen, and resistant mutants were not isolated, possibly because a mutation leading to resistance would be lethal to the RNA polymerase function.
PMID:
25296868
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25296868
Characterization of Susceptibility Variants of Influenza Virus Grown in the Presence of T-705.
Daikoku T1, Yoshida Y, Okuda T, Shiraki K.
Author information
Abstract
T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strain had amino acid variations in the PB1, PB2, and PA genes of the RNA polymerase complex. However, the variation patterns in the RNA polymerase complex indicated that T-705 does not work as a mutagen, and resistant mutants were not isolated, possibly because a mutation leading to resistance would be lethal to the RNA polymerase function.
PMID:
25296868
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25296868