tetano
Editor, Senior Moderator
J Nat Med. 2018 Apr 5. doi: 10.1007/s11418-018-1208-8. [Epub ahead of print]
[h=1]Chemical constituents from Canarium album Raeusch and their anti-influenza A virus activities.[/h] Yang LP[SUP]1[/SUP], Gu XL[SUP]1[/SUP], Chen JX[SUP]1[/SUP], Yang J[SUP]1[/SUP], Tan SY[SUP]1[/SUP], Duan WJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Two new dyhydrophaseic acid glucoside isomers, (1'S, 3'R, 5'S, 8'R, 2Z, 4E)-dihydrophaseic acid-3'-O-β-D-glucopyranoside (2) and (1'R, 3'S, 5'R, 8'R, 2Z, 4E)-dihydrophaseic acid-3'-O-β-D-glucopyranoside (4), together with 10 known compounds [myo-inositol (1), 3,4-dihydroxybenzoic acid (3), 3-O-galloyl quinic acid (5), ellagic acid (6), gallic acid (7), ethyl gallate (8), scopoletin (9), ellagic acid-4-O-β-D-glucopyranoside (10), ellagic acid-4-O-α-L-rhamnopyranoside (11), and isocorilagin (12)] were isolated from the chloroform extract of Canarium album Raeusch fruits by repeated chromatography on macroporous adsorption resin, silica gel, Sephadex LH-20, Toyopearl HW-40F, and reverse-phase C18 columns, etc. Their structures and absolute configurations were determined by comprehensive analysis of 1D- and 2D-nuclear magnetic resonance (NMR), high-resolution electron spray ionization mass spectrometry (HR-ESI-MS), ESI-MS, optical rotation, circular dichroism spectra, and comparison of NMR data with data of known compounds. Bioassay of their anti-influenza virus A activities showed that compounds 9 and 12 displayed a significant inhibitory effect with IC[SUB]50[/SUB] values of 22.9 ? 3.7 and 5.42 ? 0.97 μg/ml, respectively.
[h=4]KEYWORDS:[/h] Anti-influenza virus A activities; Canarium album Raeusch fruit; Chloroform extract; Dihydrophaseic acid glucopyranoside isomer
PMID: 29623508 DOI: 10.1007/s11418-018-1208-8
[h=1]Chemical constituents from Canarium album Raeusch and their anti-influenza A virus activities.[/h] Yang LP[SUP]1[/SUP], Gu XL[SUP]1[/SUP], Chen JX[SUP]1[/SUP], Yang J[SUP]1[/SUP], Tan SY[SUP]1[/SUP], Duan WJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Two new dyhydrophaseic acid glucoside isomers, (1'S, 3'R, 5'S, 8'R, 2Z, 4E)-dihydrophaseic acid-3'-O-β-D-glucopyranoside (2) and (1'R, 3'S, 5'R, 8'R, 2Z, 4E)-dihydrophaseic acid-3'-O-β-D-glucopyranoside (4), together with 10 known compounds [myo-inositol (1), 3,4-dihydroxybenzoic acid (3), 3-O-galloyl quinic acid (5), ellagic acid (6), gallic acid (7), ethyl gallate (8), scopoletin (9), ellagic acid-4-O-β-D-glucopyranoside (10), ellagic acid-4-O-α-L-rhamnopyranoside (11), and isocorilagin (12)] were isolated from the chloroform extract of Canarium album Raeusch fruits by repeated chromatography on macroporous adsorption resin, silica gel, Sephadex LH-20, Toyopearl HW-40F, and reverse-phase C18 columns, etc. Their structures and absolute configurations were determined by comprehensive analysis of 1D- and 2D-nuclear magnetic resonance (NMR), high-resolution electron spray ionization mass spectrometry (HR-ESI-MS), ESI-MS, optical rotation, circular dichroism spectra, and comparison of NMR data with data of known compounds. Bioassay of their anti-influenza virus A activities showed that compounds 9 and 12 displayed a significant inhibitory effect with IC[SUB]50[/SUB] values of 22.9 ? 3.7 and 5.42 ? 0.97 μg/ml, respectively.
[h=4]KEYWORDS:[/h] Anti-influenza virus A activities; Canarium album Raeusch fruit; Chloroform extract; Dihydrophaseic acid glucopyranoside isomer
PMID: 29623508 DOI: 10.1007/s11418-018-1208-8