tetano
Editor, Senior Moderator
Chemotherapy
. 2021 Mar 18;1-5.
doi: 10.1159/000515342. Online ahead of print.
Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis
Domenico Benvenuto[SUP] 1 [/SUP], Francesca Benedetti[SUP] 2 [/SUP], Ayse Banu Demir[SUP] 3 [/SUP], Massimo Ciccozzi[SUP] 1 [/SUP], Davide Zella[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths.
Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy.
Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID.
Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein.
Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.
Keywords: Bioinformatic; Coronavirus disease 2019; Evolutionary analysis; Protein modeling; Syndrome coronavirus 2.
. 2021 Mar 18;1-5.
doi: 10.1159/000515342. Online ahead of print.
Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis
Domenico Benvenuto[SUP] 1 [/SUP], Francesca Benedetti[SUP] 2 [/SUP], Ayse Banu Demir[SUP] 3 [/SUP], Massimo Ciccozzi[SUP] 1 [/SUP], Davide Zella[SUP] 4 [/SUP]
Affiliations
- PMID: 33735872
- DOI: 10.1159/000515342
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths.
Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy.
Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID.
Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein.
Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.
Keywords: Bioinformatic; Coronavirus disease 2019; Evolutionary analysis; Protein modeling; Syndrome coronavirus 2.