tetano
Editor, Senior Moderator
Chest
. 2025 Jan 21:S0012-3692(25)00105-9.
doi: 10.1016/j.chest.2025.01.012. Online ahead of print. Long-term Mental Health Morbidity in Adult Survivors of COVID-19 Critical Illness - A Population-based Cohort Study
Shannon M Fernando[SUP] 1 [/SUP], Danial Qureshi[SUP] 2 [/SUP], Robert Talarico[SUP] 3 [/SUP], Eddy Fan[SUP] 4 [/SUP], Daniel I McIsaac[SUP] 5 [/SUP], Simone N Vigod[SUP] 6 [/SUP], Manish M Sood[SUP] 7 [/SUP], Daniel T Myran[SUP] 8 [/SUP], Carol L Hodgson[SUP] 9 [/SUP], Bram Rochwerg[SUP] 10 [/SUP], Laveena Munshi[SUP] 11 [/SUP], Kirsten M Fiest[SUP] 12 [/SUP], O Joseph Bienvenu[SUP] 13 [/SUP], Dale M Needham[SUP] 14 [/SUP], Daniel Brodie[SUP] 15 [/SUP], Niall D Ferguson[SUP] 4 [/SUP], Robert A Fowler[SUP] 16 [/SUP], Deborah J Cook[SUP] 10 [/SUP], Arthur S Slutsky[SUP] 17 [/SUP], Damon C Scales[SUP] 18 [/SUP], Margaret S Herridge[SUP] 4 [/SUP], Peter Tanuseputro[SUP] 19 [/SUP], Kwadwo Kyeremanteng[SUP] 20 [/SUP]
Affiliations
Background: Survivorship after coronavirus disease 2019 (COVID-19) critical illness may be associated with important long-term sequelae, but little is known regarding mental health outcomes.
Research question: What is the association between COVID-19 critical illness and new post-discharge mental health diagnoses.
Study design: AND METHODS: We conducted a population-based cohort study in Ontario, Canada (January 1, 2020-March 31, 2022). We included consecutive adult survivors (age ≥ 18 years) of COVID-19 critical illness, and compared them with consecutive adult survivors of critical illness from non-COVID-19 pneumonia. The primary outcome was a new mental health diagnosis (a composite of mood, anxiety, or related disorders; schizophrenia/psychotic disorders; and other mental health disorders) following hospital discharge. We compared patients using overlap propensity score-weighted, cause-specific proportional hazard models.
Results: We included 6,098 survivors of COVID-19 critical illness, and 2,568 adult survivors of critical illness from non-COVID-19 pneumonia at 102 centres. Incidence of new mental health diagnosis among survivors of COVID-19 critical illness was 25.3 per 100-person years (95% confidence interval [CI] 24.0-26.6), and 25.9 per 100-person years (95% CI: 24.0-27.8) among non-COVID-19 pneumonia. Following propensity weighting, COVID-19 critical illness was not associated with increased risk of new mental health diagnosis overall (hazard ratio
1.08 [95% CI: 0.96-1.23]), but was associated with increased risk in the category of new mood, anxiety, or related disorders (HR 1.21 [95% CI: 1.05-1.40]). No difference was seen in psychotic disorders, other mental health diagnoses, social problems, or deliberate self-harm.
Interpretation: As compared to survival after critical illness from non-COVID-19 pneumonia, survival after COVID-19 critical illness was not associated with increased risk of the composite outcome of new mental health diagnosis, but was associated with elevated risk for new mood, anxiety, or related disorders.
Keywords: COVID-19; Chronic Critical Illness; Intensive Care; Mental Health; Post-Intensive Care Syndrome; Self-Harm; Suicide.
. 2025 Jan 21:S0012-3692(25)00105-9.
doi: 10.1016/j.chest.2025.01.012. Online ahead of print. Long-term Mental Health Morbidity in Adult Survivors of COVID-19 Critical Illness - A Population-based Cohort Study
Shannon M Fernando[SUP] 1 [/SUP], Danial Qureshi[SUP] 2 [/SUP], Robert Talarico[SUP] 3 [/SUP], Eddy Fan[SUP] 4 [/SUP], Daniel I McIsaac[SUP] 5 [/SUP], Simone N Vigod[SUP] 6 [/SUP], Manish M Sood[SUP] 7 [/SUP], Daniel T Myran[SUP] 8 [/SUP], Carol L Hodgson[SUP] 9 [/SUP], Bram Rochwerg[SUP] 10 [/SUP], Laveena Munshi[SUP] 11 [/SUP], Kirsten M Fiest[SUP] 12 [/SUP], O Joseph Bienvenu[SUP] 13 [/SUP], Dale M Needham[SUP] 14 [/SUP], Daniel Brodie[SUP] 15 [/SUP], Niall D Ferguson[SUP] 4 [/SUP], Robert A Fowler[SUP] 16 [/SUP], Deborah J Cook[SUP] 10 [/SUP], Arthur S Slutsky[SUP] 17 [/SUP], Damon C Scales[SUP] 18 [/SUP], Margaret S Herridge[SUP] 4 [/SUP], Peter Tanuseputro[SUP] 19 [/SUP], Kwadwo Kyeremanteng[SUP] 20 [/SUP]
Affiliations
- PMID: 39848569
- DOI: 10.1016/j.chest.2025.01.012
Background: Survivorship after coronavirus disease 2019 (COVID-19) critical illness may be associated with important long-term sequelae, but little is known regarding mental health outcomes.
Research question: What is the association between COVID-19 critical illness and new post-discharge mental health diagnoses.
Study design: AND METHODS: We conducted a population-based cohort study in Ontario, Canada (January 1, 2020-March 31, 2022). We included consecutive adult survivors (age ≥ 18 years) of COVID-19 critical illness, and compared them with consecutive adult survivors of critical illness from non-COVID-19 pneumonia. The primary outcome was a new mental health diagnosis (a composite of mood, anxiety, or related disorders; schizophrenia/psychotic disorders; and other mental health disorders) following hospital discharge. We compared patients using overlap propensity score-weighted, cause-specific proportional hazard models.
Results: We included 6,098 survivors of COVID-19 critical illness, and 2,568 adult survivors of critical illness from non-COVID-19 pneumonia at 102 centres. Incidence of new mental health diagnosis among survivors of COVID-19 critical illness was 25.3 per 100-person years (95% confidence interval [CI] 24.0-26.6), and 25.9 per 100-person years (95% CI: 24.0-27.8) among non-COVID-19 pneumonia. Following propensity weighting, COVID-19 critical illness was not associated with increased risk of new mental health diagnosis overall (hazard ratio
1.08 [95% CI: 0.96-1.23]), but was associated with increased risk in the category of new mood, anxiety, or related disorders (HR 1.21 [95% CI: 1.05-1.40]). No difference was seen in psychotic disorders, other mental health diagnoses, social problems, or deliberate self-harm.
Interpretation: As compared to survival after critical illness from non-COVID-19 pneumonia, survival after COVID-19 critical illness was not associated with increased risk of the composite outcome of new mental health diagnosis, but was associated with elevated risk for new mood, anxiety, or related disorders.
Keywords: COVID-19; Chronic Critical Illness; Intensive Care; Mental Health; Post-Intensive Care Syndrome; Self-Harm; Suicide.
