Giuseppe
Emeritus
[Source: Chest, full page: (LINK). Abstract, edited.]
Original Research | December 12, 2013
Surfactant protein B gene polymorphism is associated with severe influenza
Kelvin K. W. To; Jie Zhou; You-Qiang Song; Ivan F. N. Hung; Whitney C. T. Ip; Zhong-Shan Cheng; Andy S. F. Chan; Richard Y. T. Kao; Alan K. L. Wu; Sandy Chau; Wei-Kwang Luk; Mary S. M. Ip; Kwok-Hung Chan; Kwok-Yung Yuen
Author and Funding Information: State Key Laboratory for Emerging Infectious Diseases (To, Kao, Chan, Yuen); Carol Yu Centre for Infection (To, Hung, Chan, Yuen); Research Centre of Infection and Immunology (To, Zhou, Hung, Kao, Chan, Yuen); Department of Microbiology (To, Zhou, W. C. T. Ip, Cheng, Chan, Kao, Chan, Yuen); Department of Biochemistry (Song); Department of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China (Hung, M. S. M. Ip); Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong Special Administrative Region, China (Wu); Department of Pathology, United Christian Hospital, Hong Kong Special Administrative Region, China (Chau); Department of Pathology, Tseung Kwan O Hospital, Hong Kong Special Administrative Region, China (Luk).
Correspondence to: Kwok-Yung Yuen, Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China; e-mail: kyyuen@hku.hk.
Chest. 2013. doi:10.1378/chest.13-1651 / Published online
Abstract
Background
Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza.
Methods
In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild A(H1N1)pdm09 infection, who were matched for age, sex and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with the general Han Chinese population.
Results
This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, a SNP in the surfactant protein B gene (SFTPB), was significantly associated with severe disease (odds ratio[OR]=3.37, P=4.8?10<SUP>-3</SUP>), although the P value was 0.057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed to be associated with severe disease in the univariate analysis. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR=2.087, P=0.023). Comparing to the general Han Chinese population, C/C genotype was over-represented in patients with severe A(H1N1)pdm09 infection (OR=3.232, P=5.60?10<SUP>-7</SUP>).
Conclusion
SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies.
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Original Research | December 12, 2013
Surfactant protein B gene polymorphism is associated with severe influenza
Kelvin K. W. To; Jie Zhou; You-Qiang Song; Ivan F. N. Hung; Whitney C. T. Ip; Zhong-Shan Cheng; Andy S. F. Chan; Richard Y. T. Kao; Alan K. L. Wu; Sandy Chau; Wei-Kwang Luk; Mary S. M. Ip; Kwok-Hung Chan; Kwok-Yung Yuen
Author and Funding Information: State Key Laboratory for Emerging Infectious Diseases (To, Kao, Chan, Yuen); Carol Yu Centre for Infection (To, Hung, Chan, Yuen); Research Centre of Infection and Immunology (To, Zhou, Hung, Kao, Chan, Yuen); Department of Microbiology (To, Zhou, W. C. T. Ip, Cheng, Chan, Kao, Chan, Yuen); Department of Biochemistry (Song); Department of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China (Hung, M. S. M. Ip); Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong Special Administrative Region, China (Wu); Department of Pathology, United Christian Hospital, Hong Kong Special Administrative Region, China (Chau); Department of Pathology, Tseung Kwan O Hospital, Hong Kong Special Administrative Region, China (Luk).
Correspondence to: Kwok-Yung Yuen, Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China; e-mail: kyyuen@hku.hk.
Chest. 2013. doi:10.1378/chest.13-1651 / Published online
Abstract
Background
Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza.
Methods
In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild A(H1N1)pdm09 infection, who were matched for age, sex and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with the general Han Chinese population.
Results
This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, a SNP in the surfactant protein B gene (SFTPB), was significantly associated with severe disease (odds ratio[OR]=3.37, P=4.8?10<SUP>-3</SUP>), although the P value was 0.057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed to be associated with severe disease in the univariate analysis. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR=2.087, P=0.023). Comparing to the general Han Chinese population, C/C genotype was over-represented in patients with severe A(H1N1)pdm09 infection (OR=3.232, P=5.60?10<SUP>-7</SUP>).
Conclusion
SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies.
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