tetano
Editor, Senior Moderator
Children (Basel)
. 2021 Oct 13;8(10):913.
doi: 10.3390/children8100913.
Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
Shoichi Shimizu[SUP] 1 [/SUP], Mamoru Ayusawa[SUP] 1 [/SUP], Hidetoshi Go[SUP] 1 [/SUP], Kimitaka Nakazaki[SUP] 1 [/SUP], Hidemasa Namiki[SUP] 1 [/SUP], Yuki Kasuga[SUP] 1 [/SUP], Koji Nishimura[SUP] 1 [/SUP], Koji Kanezawa[SUP] 1 [/SUP], Tamaki Morohashi[SUP] 1 [/SUP], Ichiro Morioka[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and has a large number of registered cases.
Methods: We compared patients with KD under the period of the COVID-19 pandemic in Japan with the report from Italy during its reported period by a retrospective, cohort, observational study in a Japanese single center.
Results: Thirty-two patients with typical KD were treated during the study period, while the Italian study reported 10 patients with the signs of KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and one and no patients developed the macrophage activation syndrome (MAS) and Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and KDSS developed in six and five patients, respectively.
Conclusions: Cases reported as COVID-19 pandemic-related KD in Italy showed significantly different clinical characteristics from the typical KD symptoms known in Japan. Although they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same etiology of our 'classic' KD at the present stage.
Keywords: Japan; Kawasaki disease; coronavirus disease 2019; pandemic; severe acute respiratory syndrome coronavirus type 2; vasculitis.
. 2021 Oct 13;8(10):913.
doi: 10.3390/children8100913.
Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
Shoichi Shimizu[SUP] 1 [/SUP], Mamoru Ayusawa[SUP] 1 [/SUP], Hidetoshi Go[SUP] 1 [/SUP], Kimitaka Nakazaki[SUP] 1 [/SUP], Hidemasa Namiki[SUP] 1 [/SUP], Yuki Kasuga[SUP] 1 [/SUP], Koji Nishimura[SUP] 1 [/SUP], Koji Kanezawa[SUP] 1 [/SUP], Tamaki Morohashi[SUP] 1 [/SUP], Ichiro Morioka[SUP] 1 [/SUP]
Affiliations
- PMID: 34682178
- PMCID: PMC8535006
- DOI: 10.3390/children8100913
Abstract
Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and has a large number of registered cases.
Methods: We compared patients with KD under the period of the COVID-19 pandemic in Japan with the report from Italy during its reported period by a retrospective, cohort, observational study in a Japanese single center.
Results: Thirty-two patients with typical KD were treated during the study period, while the Italian study reported 10 patients with the signs of KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and one and no patients developed the macrophage activation syndrome (MAS) and Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and KDSS developed in six and five patients, respectively.
Conclusions: Cases reported as COVID-19 pandemic-related KD in Italy showed significantly different clinical characteristics from the typical KD symptoms known in Japan. Although they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same etiology of our 'classic' KD at the present stage.
Keywords: Japan; Kawasaki disease; coronavirus disease 2019; pandemic; severe acute respiratory syndrome coronavirus type 2; vasculitis.