tetano
Editor, Senior Moderator
China CDC Wkly
. 2022 Jan 28;4(4):57-65.
doi: 10.46234/ccdcw2022.009.
Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic, Pneumonia, and Severe Disease Caused by the Delta Variant: Real World Study and Evidence - China, 2021
Dan Wu[SUP] 1 [/SUP], Yanyang Zhang[SUP] 2 [/SUP], Lin Tang[SUP] 1 [/SUP], Fuzhen Wang[SUP] 1 [/SUP], Ying Ye[SUP] 2 [/SUP], Chao Ma[SUP] 1 [/SUP], Hui Zheng[SUP] 1 [/SUP], Wenzhou Yu[SUP] 1 [/SUP], Lei Cao[SUP] 1 [/SUP], Yifan Song[SUP] 1 [/SUP], Abuduwaili Reyimu[SUP] 3 4 [/SUP], Xiaoxiao Zhang[SUP] 2 [/SUP], Haifeng Wang[SUP] 1 [/SUP], Yifei Nie[SUP] 2 [/SUP], Mingxia Lu[SUP] 2 [/SUP], Muge Qi[SUP] 2 [/SUP], Jun Li[SUP] 2 [/SUP], Ruolin Wang[SUP] 2 [/SUP], Kaichao Yang[SUP] 2 [/SUP], Changshuang Wang[SUP] 2 [/SUP], Lawrence Everett Rodewald[SUP] 1 [/SUP], Geroge Fu Gao[SUP] 1 [/SUP], Zhijie An[SUP] 1 [/SUP], Zundong Yin[SUP] 1 [/SUP]
Affiliations
Abstract
What is already known about this topic?: Effectiveness of China's 2 inactivated vaccines (BBIBP-CorV and CoronaVac) against pre-Delta severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants ranged from 47% to over 90%, depending on the clinical endpoint, and with greater effectiveness against more severe coronavirus disease 2019 (COVID-19). During an outbreak in Guangdong, inactivated vaccine effectiveness (VE) against the Delta variant was 70% for symptomatic infection and 100% for severe COVID-19. However, separate or combined VE estimates for the two inactivated vaccines against Delta are not available.
What is added by this report?: In an outbreak that started in a hospital, VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant were 51%, 61%, and 82%. Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%. VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar, and partial vaccination was ineffective.
What are the implications for public health practice?: Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant. Completion of the completed primary vaccination with two doses is necessary for protection from Delta.
Keywords: Dietary Exposure; Fipronil; Pesticides; Total Diet Study.
. 2022 Jan 28;4(4):57-65.
doi: 10.46234/ccdcw2022.009.
Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic, Pneumonia, and Severe Disease Caused by the Delta Variant: Real World Study and Evidence - China, 2021
Dan Wu[SUP] 1 [/SUP], Yanyang Zhang[SUP] 2 [/SUP], Lin Tang[SUP] 1 [/SUP], Fuzhen Wang[SUP] 1 [/SUP], Ying Ye[SUP] 2 [/SUP], Chao Ma[SUP] 1 [/SUP], Hui Zheng[SUP] 1 [/SUP], Wenzhou Yu[SUP] 1 [/SUP], Lei Cao[SUP] 1 [/SUP], Yifan Song[SUP] 1 [/SUP], Abuduwaili Reyimu[SUP] 3 4 [/SUP], Xiaoxiao Zhang[SUP] 2 [/SUP], Haifeng Wang[SUP] 1 [/SUP], Yifei Nie[SUP] 2 [/SUP], Mingxia Lu[SUP] 2 [/SUP], Muge Qi[SUP] 2 [/SUP], Jun Li[SUP] 2 [/SUP], Ruolin Wang[SUP] 2 [/SUP], Kaichao Yang[SUP] 2 [/SUP], Changshuang Wang[SUP] 2 [/SUP], Lawrence Everett Rodewald[SUP] 1 [/SUP], Geroge Fu Gao[SUP] 1 [/SUP], Zhijie An[SUP] 1 [/SUP], Zundong Yin[SUP] 1 [/SUP]
Affiliations
- PMID: 35186369
- PMCID: PMC8837442
- DOI: 10.46234/ccdcw2022.009
Abstract
What is already known about this topic?: Effectiveness of China's 2 inactivated vaccines (BBIBP-CorV and CoronaVac) against pre-Delta severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants ranged from 47% to over 90%, depending on the clinical endpoint, and with greater effectiveness against more severe coronavirus disease 2019 (COVID-19). During an outbreak in Guangdong, inactivated vaccine effectiveness (VE) against the Delta variant was 70% for symptomatic infection and 100% for severe COVID-19. However, separate or combined VE estimates for the two inactivated vaccines against Delta are not available.
What is added by this report?: In an outbreak that started in a hospital, VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant were 51%, 61%, and 82%. Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%. VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar, and partial vaccination was ineffective.
What are the implications for public health practice?: Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant. Completion of the completed primary vaccination with two doses is necessary for protection from Delta.
Keywords: Dietary Exposure; Fipronil; Pesticides; Total Diet Study.