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China - H10N8 avian influenza virus: reporter interview with Shu Yuelong (National Influenza Centre)

Pathfinder

Editor, Senior Moderator
Translation Google

No variation H10N8 virus prevention and control shall leave no successor could feed sales

February 19, 2014 09:52:01 Hangzhou Network
  
Recently, the China CDC deputy director of viral diseases, director of the National Influenza Center Shu Yuelong led the Chinese team of experts in the British medical journal "The Lancet" published papers, pointing out H10N8 avian influenza virus mutation has occurred, the human body can carry, pandemic possibility should never be underestimated. S first novel H10N8 deaths caused by the virus experts analyzed that the current interpersonal H10N8 virus spread may temporarily unmanned.
  
How rational treatment for this new problem of avian influenza virus, the reporter interviewed (National Influenza Centre) Shu Yuelong understand H10N8 discovery process, variation, spread risk, vulnerable populations, prevention and control, prevention measures. Shu Yuelong believe that taking large-scale farming and chilled poultry sales, is the ultimate way to effective prevention and control of avian influenza. Meanwhile, the people have a scientific, healthy eating habits, did not need to have seen the chicken slaughtered in front of you to eat.

H10N8 new variant
  
Can infect human lung rapid replication
  
Reporter: What are the latest discoveries H10N8 avian influenza virus in the process, the differences H10N8 virus it had found on live birds?
  
Shu Yuelong: December 6, 2012, the first patient died, was living in Nanchang, Jiangxi's 73-year-old woman, diagnosed as severe pneumonia, Nanchang CDC tested positive for influenza considered, but ruled out the known sub- type, then the sample sent to the CDC for review Jiangxi Province, reached the same conclusion, and immediately sent to the National Influenza Center. Through gene sequencing, tracheal suction samples tested for the virus by means of a detailed study and found a H10N8 avian influenza virus. It H10N8 virus in 2007 in Dongting Lake wetland water bodies, in 2012 in Guangdong found on live poultry markets are not the same, this new virus acquired the six genes from the H9N2 avian influenza virus and reorganization, can the human lung Ministry deep tissue caused by infection, and then rapidly replicate in the human body. We speculate that the earliest novel H10N8 virus from wild birds, poultry by infected with H9N2 in poultry in the popular re-equipped, and ultimately to humans.

Southern high-fat
  
Infection or associated with genetic background
  
Reporter: At present, the monitoring agency found many cases of human infection H10N8 virus? Who is susceptible?
  
Shu Yuelong: China has monitored cases H10N8 found two cases of human infection with the virus, the first patients have died; January 25 confirmed cases worldwide of the second, the same happened in Nanchang, the patient was 55-year-old woman, is currently being treated in hospital critical condition. For the first patient, she was the cause of death should be caused by many factors, viral infections, immune responses induced excesses, but she has high blood pressure, heart disease, myasthenia gravis and other basic diseases. February 8, Nanchang 75-year-old man Hu also due to infection H10N8 avian influenza virus death. Avian flu infections may have some relationship with the genetic background of some people, but the specific unclear which areas can not answer, which are more prone to infection. The more southern areas of high incidence of bird flu, may also be related to breeding patterns and the South, a relatively high density of poultry.

New virus risk

Interpersonal transmission may temporarily unmanned
  
Reporter: Why say "H10N8 pandemic possibility should never be underestimated."? How high is the risk of transmission? Will human transmission?
  
Shu Yuelong: There is no evidence that this new type of bird flu virus can be spread from person to person, but the virus that causes bird flu epidemic potential should not be underestimated, because it is a reassortant virus, we do not know what will happen change, there is a need to strengthen the monitoring prevention. Birds known to be transmitted to humans, while only the case, from the etiology of view, it is a completely determine avian virus, it now appears, the possibility of spread from person to person it is not.
  
Reporter: H10N8 and H7N9 What's the difference? Including the route of infection, the incidence of expression, human dangers and so on.
  
Shu Yuelong: H10N8 virus H5N1, H7N9 viruses have genetic similarities, the two viruses transmitted to humans by birds, cases resulting in death has occurred. Yet there H10N8 large outbreaks in poultry reported, meaning that the virus may spread in birds quietly. H10N8 and H7N9 subtypes are different, they are similar for both the low pathogenic avian, human infection manifested as severe. H10N8 currently only two cases, sporadic cases of accidental infection, can not fully explain the problem, but I think people are infected after symptoms are relatively heavy. Second, they are the same internal genes are from H9N2.
  
Reporter: In response to this virus, prevention and control of the country in what had been done?
  
Shu Yuelong: We are mainly to strengthen the monitoring of this new virus in Nanchang, after the hospital for suspected cases, requiring Nanchang, Jiangxi Province in the exclusion of other avian flu, to detect whether H10N8. Other places have not yet started work related to prevention and control.

Antivirus dilemma
  
Sales of live chickens caused by a virus reassortment
  
Reporter: At present, the spread of H7N9 avian influenza situation in our country has not yet been checked, there was H10N8, does that mean that our people infected with bird flu prevention and control work very hard?
  
Shu Yuelong: very difficult. H10N8, H7N9, including previous H5N1, H9N2, have let our prevention and control work fiasco. The reason for this situation, I think, lies in our backyard breeding patterns, live poultry sales model for the avian influenza virus reassortment offers many opportunities to generate a lot of new reassortant viruses. So to completely change this country does not have the advanced productive breeding, sales model, as well as people's eating habits, is the ultimate way to effective prevention and control of avian influenza. In other words, our culture, sales model must be upgraded towards modernization, that large-scale farming and chilled poultry sales. We see that every occurrence of bird flu, will be on our farming industry caused great shock. Now H7N9 epidemic has given us a wake-up call, it is time to fundamentally solve the problem, we must face this fact, let the poultry industry has become very safe, rather than "stop-gap" .

Precaution
  
Need to wash their hands went live bird markets
  
Reporter: Recently H7N9 vaccine research has made a major breakthrough, if there is a vaccine production H10N8 necessary? Public to this new virus to prevent infection, what measures should be taken?
  
Shu Yuelong: Now limited cases, for H10N8 vaccine research, now it seems there is no need. The two cases have been sent H10N8 have live poultry business market exposure history, people in everyday life, a scientific, healthy eating habits, did not need to have seen chickens slaughtered in front of you can eat, people want to convert ideas, gradual changes in eating habits. Since we do not eat do not eat chicken duck, but to be safe to eat. Also have good personal hygiene habits, went live bird markets, remember to wash your hands. (Text / reporter Xie Qishan)

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