I'm not sure if this is the correct place for this thread, since this is flu, but I couldn't find a better place for it:
Published Date: 2013-12-05 20:44:41
Subject: PRO/AH/EDR> Influenza, canine - China: H3N2 avian origin, RFI
Archive Number: 20131205.2095131
INFLUENZA, CANINE - CHINA: H3N2 AVIAN ORIGIN, REQUEST FOR INFORMATION
*********************************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org
Date: Wed 4 Dec 2013 [accessed]
Source: Infection, Genetics and Evolution, cited by Flutrackers [edited]
http://www.flutrackers.com/forum/showthread.php?t=214497
http://www.ncbi.nlm.nih.gov/pubmed/24298574
Avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong, China. Shuo Su, Hua-Tao Li, Fu-Rong Zhao, Ji-Dang Chen, Jie-xiong Xie, Zhong-Ming Chen, Zhen Huang, Yi-Ming Hu, Min-Ze Zhang, Li-Kai Tan, Gui-Hong Zhang, Shou-Jun Li, (2013). Infect Genet Evol.19:444-449 (short communication).
Abstract
Since 2006, more and more cases of the infectious H3N2 canine influenza virus (CIV) in pet dogs have been reported in southern China. However, little is known about the prevalence situation of H3N2 CIV infections in farmed dogs in China. This is the 1st systematic epidemiological surveillance of CIV in different dog populations in Southern China.
Two virus strains -- A/Canine/Guangdong/1/2011(H3N2) and A/canine/Guangdong/5/2011(H3N2) -- were isolated from canine nasal swabs collected at one dog farm in Guangzhou and the other farm in Shenzhen. Sequence and phylogenetic analysis of 8 gene segments of these viruses revealed that they were most similar to the newly isolated canine H3N2 viruses in dogs and cats from Korea and China, which originated from an avian strain. This indicates that H3N2 CIV may be a common pathogen for pet and farmed dog populations in southern China at present.
Serological surveillance has shown that the infection rates of this avian-origin canine influenza in farmed dogs and in pet dogs were 12.22 and 5.3 percent, respectively, as determined by ELISA. The data also suggested that transmission occurred, most probably by close contact, between H3N2 CIV infected dogs in different dog populations in recent years.
As H3N2 outbreaks among dogs continue in Guangdong Province (located very close to Hong Kong), [in densely populated areas with frequent animal trade], there is a continued risk for pet H3N2 CIV infections and for mutations or genetic reassortment leading to new virus strains with increased transmissibility among dogs. Further in-depth study is required, as H3N2 CIV has been established in different dog populations and poses a potential threat to public health.
--
Communicated by:
ProMED-mail
<promed@promedmail.org>
[The text of the full paper concluded with the following segment: "...although no direct transmission of H3N2 CIV from dogs to humans has been reported, it is possible that the CIV may generate a new pandemic outbreak, which poses a great threat to our human life. These findings highlight the importance of monitoring dogs in pet hospitals and on dog farms; furthermore, the development of a canine H3N2 vaccine is extremely urgent."
The initial genome announcement of the H3N2 canine strain from Guangdong was published in September 2012.
Reference
Shuo Su, Nan Cao, Jidang Chen, Furong Zhao, Huatao Li, Mingxi Zhao, Yanjing Wang, Zhen Huang, Liguo Yuan, Heng Wang (2012). Complete Genome Sequence of an Avian-Origin H3N2 Canine Influenza A Virus Isolated in Farmed Dogs in Southern China. Journal of Virology 86 (18),10238. http://jvi.asm.org/content/86/18/10238.full.pdf. - Mod.AS
Dendrograms based upon HA and NA sequences accompanying the original paper indicates that the canine strains are closely related to avian H3N2 strains but relatively distant from human, swine and equine strains. - Mod.LM
Published Date: 2013-12-05 20:44:41
Subject: PRO/AH/EDR> Influenza, canine - China: H3N2 avian origin, RFI
Archive Number: 20131205.2095131
INFLUENZA, CANINE - CHINA: H3N2 AVIAN ORIGIN, REQUEST FOR INFORMATION
*********************************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org
Date: Wed 4 Dec 2013 [accessed]
Source: Infection, Genetics and Evolution, cited by Flutrackers [edited]
http://www.flutrackers.com/forum/showthread.php?t=214497
http://www.ncbi.nlm.nih.gov/pubmed/24298574
Avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong, China. Shuo Su, Hua-Tao Li, Fu-Rong Zhao, Ji-Dang Chen, Jie-xiong Xie, Zhong-Ming Chen, Zhen Huang, Yi-Ming Hu, Min-Ze Zhang, Li-Kai Tan, Gui-Hong Zhang, Shou-Jun Li, (2013). Infect Genet Evol.19:444-449 (short communication).
Abstract
Since 2006, more and more cases of the infectious H3N2 canine influenza virus (CIV) in pet dogs have been reported in southern China. However, little is known about the prevalence situation of H3N2 CIV infections in farmed dogs in China. This is the 1st systematic epidemiological surveillance of CIV in different dog populations in Southern China.
Two virus strains -- A/Canine/Guangdong/1/2011(H3N2) and A/canine/Guangdong/5/2011(H3N2) -- were isolated from canine nasal swabs collected at one dog farm in Guangzhou and the other farm in Shenzhen. Sequence and phylogenetic analysis of 8 gene segments of these viruses revealed that they were most similar to the newly isolated canine H3N2 viruses in dogs and cats from Korea and China, which originated from an avian strain. This indicates that H3N2 CIV may be a common pathogen for pet and farmed dog populations in southern China at present.
Serological surveillance has shown that the infection rates of this avian-origin canine influenza in farmed dogs and in pet dogs were 12.22 and 5.3 percent, respectively, as determined by ELISA. The data also suggested that transmission occurred, most probably by close contact, between H3N2 CIV infected dogs in different dog populations in recent years.
As H3N2 outbreaks among dogs continue in Guangdong Province (located very close to Hong Kong), [in densely populated areas with frequent animal trade], there is a continued risk for pet H3N2 CIV infections and for mutations or genetic reassortment leading to new virus strains with increased transmissibility among dogs. Further in-depth study is required, as H3N2 CIV has been established in different dog populations and poses a potential threat to public health.
--
Communicated by:
ProMED-mail
<promed@promedmail.org>
[The text of the full paper concluded with the following segment: "...although no direct transmission of H3N2 CIV from dogs to humans has been reported, it is possible that the CIV may generate a new pandemic outbreak, which poses a great threat to our human life. These findings highlight the importance of monitoring dogs in pet hospitals and on dog farms; furthermore, the development of a canine H3N2 vaccine is extremely urgent."
The initial genome announcement of the H3N2 canine strain from Guangdong was published in September 2012.
Reference
Shuo Su, Nan Cao, Jidang Chen, Furong Zhao, Huatao Li, Mingxi Zhao, Yanjing Wang, Zhen Huang, Liguo Yuan, Heng Wang (2012). Complete Genome Sequence of an Avian-Origin H3N2 Canine Influenza A Virus Isolated in Farmed Dogs in Southern China. Journal of Virology 86 (18),10238. http://jvi.asm.org/content/86/18/10238.full.pdf. - Mod.AS
Dendrograms based upon HA and NA sequences accompanying the original paper indicates that the canine strains are closely related to avian H3N2 strains but relatively distant from human, swine and equine strains. - Mod.LM