tetano
Editor, Senior Moderator
Vet Res. 2018 Jul 18;49(1):65. doi: 10.1186/s13567-018-0568-0.
[h=1]Ciliostasis of airway epithelial cells facilitates influenza A virus infection.[/h] Fu Y[SUP]1,[/SUP][SUP]2[/SUP], Tong J[SUP]1[/SUP], Meng F[SUP]1[/SUP], Hoeltig D[SUP]3[/SUP], Liu G[SUP]2[/SUP], Yin X[SUP]2[/SUP], Herrler G[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Porcine precision-cut lung slices (PCLS) were used to analyze the effect of the ciliary activity on infection of airway epithelial cells by influenza viruses. Treatment of slices with 2% NaCl for 30 min resulted in reversible ciliostasis. When PCLS were infected by a swine influenza virus of the H3N2 subtype under ciliostatic conditions, the viral yield was about twofold or threefold higher at 24 or 48 h post-infection, respectively, as compared to slices with ciliary activity. Therefore, the cilia beating not only transports the mucus out of the airways, it also impedes virus infection.
PMID: 30021653 DOI: 10.1186/s13567-018-0568-0
[h=1]Ciliostasis of airway epithelial cells facilitates influenza A virus infection.[/h] Fu Y[SUP]1,[/SUP][SUP]2[/SUP], Tong J[SUP]1[/SUP], Meng F[SUP]1[/SUP], Hoeltig D[SUP]3[/SUP], Liu G[SUP]2[/SUP], Yin X[SUP]2[/SUP], Herrler G[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Porcine precision-cut lung slices (PCLS) were used to analyze the effect of the ciliary activity on infection of airway epithelial cells by influenza viruses. Treatment of slices with 2% NaCl for 30 min resulted in reversible ciliostasis. When PCLS were infected by a swine influenza virus of the H3N2 subtype under ciliostatic conditions, the viral yield was about twofold or threefold higher at 24 or 48 h post-infection, respectively, as compared to slices with ciliary activity. Therefore, the cilia beating not only transports the mucus out of the airways, it also impedes virus infection.
PMID: 30021653 DOI: 10.1186/s13567-018-0568-0