tetano
Editor, Senior Moderator
Circ J
. 2021 May 20.
doi: 10.1253/circj.CJ-21-0169. Online ahead of print.
Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan
Yugo Yamashita[SUP] 1 [/SUP], Yuuki Maruyama[SUP] 2 [/SUP], Hirono Satokawa[SUP] 3 [/SUP], Yuji Nishimoto[SUP] 4 [/SUP], Ichizo Tsujino[SUP] 5 [/SUP], Hideki Sakashita[SUP] 6 [/SUP], Hiroko Nakata[SUP] 7 [/SUP], Yoshinori Okuno[SUP] 1 [/SUP], Yoshito Ogihara[SUP] 8 [/SUP], Sen Yachi[SUP] 9 [/SUP], Naoki Toya[SUP] 10 [/SUP], Masami Shingaki[SUP] 11 [/SUP], Satoshi Ikeda[SUP] 12 [/SUP], Naoto Yamamoto[SUP] 13 [/SUP], Shizu Aikawa[SUP] 14 [/SUP], Nobutaka Ikeda[SUP] 15 [/SUP], Hiroya Hayashi[SUP] 16 [/SUP], Shingo Ishiguro[SUP] 17 [/SUP], Eriko Iwata[SUP] 18 [/SUP], Michihisa Umetsu[SUP] 19 [/SUP], Akane Kondo[SUP] 20 [/SUP], Takehisa Iwai[SUP] 21 [/SUP], Takao Kobayashi[SUP] 13 [/SUP], Makoto Mo[SUP] 22 [/SUP], Norikazu Yamada[SUP] 23 [/SUP], Taskforce of VTE and COVID-19 in Japan Study
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.Methods and Results:The VTE and COVID-19 in Japan Study is a retrospective, multicenter cohort study enrolling hospitalized patients with COVID-19 who were evaluated with contrast-enhanced computed tomography (CT) examination at 22 centers in Japan between March 2020 and October 2020. Among 1,236 patients with COVID-19, 45 (3.6%) were evaluated with contrast-enhanced CT examination. VTE events occurred in 10 patients (22.2%), and the incidence of VTE in mild, moderate, and severe COVID-19 was 0%, 11.8%, and 40.0%, respectively. COVID-19 patients with VTE showed a higher body weight (81.6 vs. 64.0 kg, P=0.005) and body mass index (26.9 vs. 23.2 kg/m[SUP]2[/SUP], P=0.04), and a higher proportion had a severe status for COVID-19 compared with those without. There was no significant difference in the proportion of patients alive at discharge between patients with and without VTE (80.0% vs. 88.6%, P=0.48). Among 8 pulmonary embolism (PE) patients, all were low-risk PE.
Conclusions: Among a relatively small number of patients undergoing contrast-enhanced CT examination in Japanese real-world clinical practice, there were no VTE patients among those with mild COVID-19, but the incidence of VTE seemed to be relatively high among severe COVID-19 patients, although all PE events were low-risk without significant effect on mortality risk.
Keywords: Asians; Coronavirus disease 2019 (COVID-19); Japan; Pulmonary embolism; Venous thromboembolism.
. 2021 May 20.
doi: 10.1253/circj.CJ-21-0169. Online ahead of print.
Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan
Yugo Yamashita[SUP] 1 [/SUP], Yuuki Maruyama[SUP] 2 [/SUP], Hirono Satokawa[SUP] 3 [/SUP], Yuji Nishimoto[SUP] 4 [/SUP], Ichizo Tsujino[SUP] 5 [/SUP], Hideki Sakashita[SUP] 6 [/SUP], Hiroko Nakata[SUP] 7 [/SUP], Yoshinori Okuno[SUP] 1 [/SUP], Yoshito Ogihara[SUP] 8 [/SUP], Sen Yachi[SUP] 9 [/SUP], Naoki Toya[SUP] 10 [/SUP], Masami Shingaki[SUP] 11 [/SUP], Satoshi Ikeda[SUP] 12 [/SUP], Naoto Yamamoto[SUP] 13 [/SUP], Shizu Aikawa[SUP] 14 [/SUP], Nobutaka Ikeda[SUP] 15 [/SUP], Hiroya Hayashi[SUP] 16 [/SUP], Shingo Ishiguro[SUP] 17 [/SUP], Eriko Iwata[SUP] 18 [/SUP], Michihisa Umetsu[SUP] 19 [/SUP], Akane Kondo[SUP] 20 [/SUP], Takehisa Iwai[SUP] 21 [/SUP], Takao Kobayashi[SUP] 13 [/SUP], Makoto Mo[SUP] 22 [/SUP], Norikazu Yamada[SUP] 23 [/SUP], Taskforce of VTE and COVID-19 in Japan Study
Affiliations
- PMID: 34011824
- DOI: 10.1253/circj.CJ-21-0169
Abstract
Background: Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.Methods and Results:The VTE and COVID-19 in Japan Study is a retrospective, multicenter cohort study enrolling hospitalized patients with COVID-19 who were evaluated with contrast-enhanced computed tomography (CT) examination at 22 centers in Japan between March 2020 and October 2020. Among 1,236 patients with COVID-19, 45 (3.6%) were evaluated with contrast-enhanced CT examination. VTE events occurred in 10 patients (22.2%), and the incidence of VTE in mild, moderate, and severe COVID-19 was 0%, 11.8%, and 40.0%, respectively. COVID-19 patients with VTE showed a higher body weight (81.6 vs. 64.0 kg, P=0.005) and body mass index (26.9 vs. 23.2 kg/m[SUP]2[/SUP], P=0.04), and a higher proportion had a severe status for COVID-19 compared with those without. There was no significant difference in the proportion of patients alive at discharge between patients with and without VTE (80.0% vs. 88.6%, P=0.48). Among 8 pulmonary embolism (PE) patients, all were low-risk PE.
Conclusions: Among a relatively small number of patients undergoing contrast-enhanced CT examination in Japanese real-world clinical practice, there were no VTE patients among those with mild COVID-19, but the incidence of VTE seemed to be relatively high among severe COVID-19 patients, although all PE events were low-risk without significant effect on mortality risk.
Keywords: Asians; Coronavirus disease 2019 (COVID-19); Japan; Pulmonary embolism; Venous thromboembolism.