tetano
Editor, Senior Moderator
Circ J
. 2022 Jan 26.
doi: 10.1253/circj.CJ-21-0911. Online ahead of print.
New-Onset Atrial Fibrillation in Patients With Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease - Insights From the CLAVIS-COVID Registry
Takahide Sano[SUP] 1 [/SUP], Shingo Matsumoto[SUP] 2 [/SUP], Takanori Ikeda[SUP] 1 [/SUP], Shunsuke Kuroda[SUP] 3 [/SUP], Takeshi Kitai[SUP] 4 [/SUP], Taishi Yonetsu[SUP] 5 [/SUP], Shun Kohsaka[SUP] 6 [/SUP], Sho Torii[SUP] 7 [/SUP], Koichi Node[SUP] 8 [/SUP], Yuya Matsue[SUP] 9 10 [/SUP]
Affiliations
Abstract
Background: Both pre-existing atrial fibrillation (AF) and new-onset AF (NOAF) are observed in patients with coronavirus disease 2019 (COVID-19); however, the effect of AF on clinical outcomes is unclear. This study aimed to investigate the effect of AF, especially NOAF, on the outcomes of hospitalized patients with COVID-19.Methods and Results:This study analyzed 673 COVID-19 patients with cardiovascular diseases and risk factors (CVDRF). Patients were divided into 3 groups; pre-existing AF (n=55), NOAF (n=28), and sinus rhythm (SR) (n=590). The baseline characteristics and in-hospital outcomes were evaluated. The mean age of the patients was 68 years, 65.4% were male, and the in-hospital mortality rate was 15.6%. The NOAF group demonstrated a higher in-hospital mortality rate (42.9%) than the pre-existing AF (30.9%) and SR (11.2%) groups (P<0.001). Patients with NOAF had a higher incidence of acute respiratory syndrome, multiple organ disease, hemorrhage, and stroke than those with pre-existing AF and NOAF. NOAF was independently associated with in-hospital mortality after adjusting for pre-existing AF and 4C mortality score (odds ratio [95% confidence interval]: 4.71 [1.63-13.6], P<0.001).
Conclusions: Patients with NOAF had significantly worse outcomes as compared to patients with pre-existing AF and SR. The incidence of NOAF would be a useful predictor of clinical outcomes during hospitalization.
Keywords: Atrial fibrillation; COVID-19; Cardiovascular diseases; Japan; Mortality.
. 2022 Jan 26.
doi: 10.1253/circj.CJ-21-0911. Online ahead of print.
New-Onset Atrial Fibrillation in Patients With Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease - Insights From the CLAVIS-COVID Registry
Takahide Sano[SUP] 1 [/SUP], Shingo Matsumoto[SUP] 2 [/SUP], Takanori Ikeda[SUP] 1 [/SUP], Shunsuke Kuroda[SUP] 3 [/SUP], Takeshi Kitai[SUP] 4 [/SUP], Taishi Yonetsu[SUP] 5 [/SUP], Shun Kohsaka[SUP] 6 [/SUP], Sho Torii[SUP] 7 [/SUP], Koichi Node[SUP] 8 [/SUP], Yuya Matsue[SUP] 9 10 [/SUP]
Affiliations
- PMID: 35082216
- DOI: 10.1253/circj.CJ-21-0911
Abstract
Background: Both pre-existing atrial fibrillation (AF) and new-onset AF (NOAF) are observed in patients with coronavirus disease 2019 (COVID-19); however, the effect of AF on clinical outcomes is unclear. This study aimed to investigate the effect of AF, especially NOAF, on the outcomes of hospitalized patients with COVID-19.Methods and Results:This study analyzed 673 COVID-19 patients with cardiovascular diseases and risk factors (CVDRF). Patients were divided into 3 groups; pre-existing AF (n=55), NOAF (n=28), and sinus rhythm (SR) (n=590). The baseline characteristics and in-hospital outcomes were evaluated. The mean age of the patients was 68 years, 65.4% were male, and the in-hospital mortality rate was 15.6%. The NOAF group demonstrated a higher in-hospital mortality rate (42.9%) than the pre-existing AF (30.9%) and SR (11.2%) groups (P<0.001). Patients with NOAF had a higher incidence of acute respiratory syndrome, multiple organ disease, hemorrhage, and stroke than those with pre-existing AF and NOAF. NOAF was independently associated with in-hospital mortality after adjusting for pre-existing AF and 4C mortality score (odds ratio [95% confidence interval]: 4.71 [1.63-13.6], P<0.001).
Conclusions: Patients with NOAF had significantly worse outcomes as compared to patients with pre-existing AF and SR. The incidence of NOAF would be a useful predictor of clinical outcomes during hospitalization.
Keywords: Atrial fibrillation; COVID-19; Cardiovascular diseases; Japan; Mortality.