tetano
Editor, Senior Moderator
Circ Rep
. 2022 Mar 31;4(5):215-221.
doi: 10.1253/circrep.CR-22-0022. eCollection 2022 May 10.
D-Dimer Values and Venous Thromboembolism in Patients With COVID-19 in Japan - From the CLOT-COVID Study
Nobutaka Ikeda[SUP] 1 [/SUP], Sen Yachi[SUP] 2 [/SUP], Makoto Takeyama[SUP] 2 [/SUP], Yuji Nishimoto[SUP] 3 [/SUP], Ichizo Tsujino[SUP] 4 [/SUP], Junichi Nakamura[SUP] 4 [/SUP], Naoto Yamamoto[SUP] 5 [/SUP], Hiroko Nakata[SUP] 6 [/SUP], Satoshi Ikeda[SUP] 7 [/SUP], Michihisa Umetsu[SUP] 8 [/SUP], Shizu Aikawa[SUP] 9 [/SUP], Hiroya Hayashi[SUP] 10 [/SUP], Hirono Satokawa[SUP] 11 [/SUP], Yoshinori Okuno[SUP] 12 [/SUP], Eriko Iwata[SUP] 13 [/SUP], Yoshito Ogihara[SUP] 14 [/SUP], Akane Kondo[SUP] 15 [/SUP], Takehisa Iwai[SUP] 16 [/SUP], Norikazu Yamada[SUP] 17 [/SUP], Tomohiro Ogawa[SUP] 18 [/SUP], Takao Kobayashi[SUP] 5 [/SUP], Makoto Mo[SUP] 19 [/SUP], Yugo Yamashita[SUP] 12 [/SUP], CLOT-COVID Study Investigators
Affiliations
Abstract
Background: To date, there are no large-scale data on the association between D-dimer levels at admission and the occurrence of venous thromboembolism (VTE) in Japanese patients with coronavirus disease 2019 (COVID-19). Methods and Results: The CLOT-COVID study was a retrospective, multicenter cohort study enrolling consecutive hospitalized patients with COVID-19 across 16 centers in Japan from April 2021 to September 2021. Among 2,894 enrolled patients, 2,771 (96%) had D-dimer levels measured at admission. Patients were divided into 3 groups based on tertiles of D-dimer levels at admission (1st tertile, D-dimer ≤0.5 μg/mL, n=949; 2nd tertile, D-dimer 0.51-1.09 μg/mL, n=894; 3rd tertile, D-dimer ≥1.1 μg/mL, n=928). The higher the tertile group, the more severe the COVID-19 status at admission. The incidence of VTE during hospitalization was highest in the 3rd tertile group (1st tertile, 0.3%; 2nd tertile, 0.3%; 3rd tertile, 3.6%; P<0.001). Even after adjusting for confounders in the multivariable logistic regression model, the higher D-dimer levels in the 3rd tertile (≥1.1 μg/mL) were independently associated with a higher risk of VTE during hospitalization (adjusted odds ratio 4.83 [95% confidence interval 1.93-12.11; P<0.001]; reference=1st tertile). Conclusions: Higher D-dimer levels at admission were associated with a higher risk of VTE events during hospitalization in Japanese patients with COVID-19. This could be helpful in determining patient-specific anticoagulation management strategies for COVID-19 in Japan.
Keywords: COVID-19; D-dimer; Venous thromboembolism.
. 2022 Mar 31;4(5):215-221.
doi: 10.1253/circrep.CR-22-0022. eCollection 2022 May 10.
D-Dimer Values and Venous Thromboembolism in Patients With COVID-19 in Japan - From the CLOT-COVID Study
Nobutaka Ikeda[SUP] 1 [/SUP], Sen Yachi[SUP] 2 [/SUP], Makoto Takeyama[SUP] 2 [/SUP], Yuji Nishimoto[SUP] 3 [/SUP], Ichizo Tsujino[SUP] 4 [/SUP], Junichi Nakamura[SUP] 4 [/SUP], Naoto Yamamoto[SUP] 5 [/SUP], Hiroko Nakata[SUP] 6 [/SUP], Satoshi Ikeda[SUP] 7 [/SUP], Michihisa Umetsu[SUP] 8 [/SUP], Shizu Aikawa[SUP] 9 [/SUP], Hiroya Hayashi[SUP] 10 [/SUP], Hirono Satokawa[SUP] 11 [/SUP], Yoshinori Okuno[SUP] 12 [/SUP], Eriko Iwata[SUP] 13 [/SUP], Yoshito Ogihara[SUP] 14 [/SUP], Akane Kondo[SUP] 15 [/SUP], Takehisa Iwai[SUP] 16 [/SUP], Norikazu Yamada[SUP] 17 [/SUP], Tomohiro Ogawa[SUP] 18 [/SUP], Takao Kobayashi[SUP] 5 [/SUP], Makoto Mo[SUP] 19 [/SUP], Yugo Yamashita[SUP] 12 [/SUP], CLOT-COVID Study Investigators
Affiliations
- PMID: 35600720
- PMCID: PMC9072098
- DOI: 10.1253/circrep.CR-22-0022
Abstract
Background: To date, there are no large-scale data on the association between D-dimer levels at admission and the occurrence of venous thromboembolism (VTE) in Japanese patients with coronavirus disease 2019 (COVID-19). Methods and Results: The CLOT-COVID study was a retrospective, multicenter cohort study enrolling consecutive hospitalized patients with COVID-19 across 16 centers in Japan from April 2021 to September 2021. Among 2,894 enrolled patients, 2,771 (96%) had D-dimer levels measured at admission. Patients were divided into 3 groups based on tertiles of D-dimer levels at admission (1st tertile, D-dimer ≤0.5 μg/mL, n=949; 2nd tertile, D-dimer 0.51-1.09 μg/mL, n=894; 3rd tertile, D-dimer ≥1.1 μg/mL, n=928). The higher the tertile group, the more severe the COVID-19 status at admission. The incidence of VTE during hospitalization was highest in the 3rd tertile group (1st tertile, 0.3%; 2nd tertile, 0.3%; 3rd tertile, 3.6%; P<0.001). Even after adjusting for confounders in the multivariable logistic regression model, the higher D-dimer levels in the 3rd tertile (≥1.1 μg/mL) were independently associated with a higher risk of VTE during hospitalization (adjusted odds ratio 4.83 [95% confidence interval 1.93-12.11; P<0.001]; reference=1st tertile). Conclusions: Higher D-dimer levels at admission were associated with a higher risk of VTE events during hospitalization in Japanese patients with COVID-19. This could be helpful in determining patient-specific anticoagulation management strategies for COVID-19 in Japan.
Keywords: COVID-19; D-dimer; Venous thromboembolism.