tetano
Editor, Senior Moderator
AIDS. 2018 Apr 19. doi: 10.1097/QAD.0000000000001821. [Epub ahead of print]
[h=1]Circulating inflammatory monocytes contribute to impaired influenza vaccine responses in HIV-infected participants.[/h] George VK[SUP]1[/SUP], Pallikkuth S, Pahwa R, de Armas L, Rinaldi S, Pan L, Pahwa S.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] Antibody responses are often impaired in old age and in HIV+ infection despite virologic control with antiretroviral therapy but innate immunologic determinants are not well understood.
[h=4]DESIGN:[/h] Monocytes and natural killer cells were examined for relationships to age, HIV infection and influenza vaccine responses.
[h=4]METHODS:[/h] Virologically suppressed HIV+ (n = 139) and HIV- (n = 137) participants classified by age as young (18-39 years), middle-aged (40-59 years) and old (≥60 years) were evaluated preinfluenza and postinfluenza vaccination.
[h=4]RESULTS:[/h] Prevaccination frequencies of inflammatory monocytes were highest in old HIV+ and HIV-, with old HIV+ exhibiting higher frequency of integrin CD11b on inflammatory monocytes that was correlated with age, expression of C-C chemokine receptor-2 (CCR2) and plasma soluble tumor necrosis factor receptor-1 (sTNFR1), with inverse correlation with postvaccination influenza H1N1 antibody titers. Higher frequencies of CD11b inflammatory monocytes (CD11b, >48.4%) compared with low frequencies of CD11b inflammatory monocytes (<15.8%) was associated with higher prevaccination frequencies of total and inflammatory monocytes and higher CCR2 MFI, higher plasma sTNFR1 and CXCL-10 with higher LPS stimulated expression of TNFα and IL-6, concomitant with lower postvaccination influenza antibody titers. In HIV+ CD11b expressers, the depletion of inflammatory monocytes from PBMC resulted in enhanced antigen-specific CD4 T-cell proliferation. Immature CD56 natural killer cells were lower in young HIV+ compared with young HIV- participants.
[h=4]CONCLUSION:[/h] Perturbations of innate immunity and inflammation signified by high CD11b on inflammatory monocytes are exacerbated with aging in HIV+ and negatively impact immune function involved in Ab response to influenza vaccination.
PMID: 29683844 DOI: 10.1097/QAD.0000000000001821
[h=1]Circulating inflammatory monocytes contribute to impaired influenza vaccine responses in HIV-infected participants.[/h] George VK[SUP]1[/SUP], Pallikkuth S, Pahwa R, de Armas L, Rinaldi S, Pan L, Pahwa S.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] Antibody responses are often impaired in old age and in HIV+ infection despite virologic control with antiretroviral therapy but innate immunologic determinants are not well understood.
[h=4]DESIGN:[/h] Monocytes and natural killer cells were examined for relationships to age, HIV infection and influenza vaccine responses.
[h=4]METHODS:[/h] Virologically suppressed HIV+ (n = 139) and HIV- (n = 137) participants classified by age as young (18-39 years), middle-aged (40-59 years) and old (≥60 years) were evaluated preinfluenza and postinfluenza vaccination.
[h=4]RESULTS:[/h] Prevaccination frequencies of inflammatory monocytes were highest in old HIV+ and HIV-, with old HIV+ exhibiting higher frequency of integrin CD11b on inflammatory monocytes that was correlated with age, expression of C-C chemokine receptor-2 (CCR2) and plasma soluble tumor necrosis factor receptor-1 (sTNFR1), with inverse correlation with postvaccination influenza H1N1 antibody titers. Higher frequencies of CD11b inflammatory monocytes (CD11b, >48.4%) compared with low frequencies of CD11b inflammatory monocytes (<15.8%) was associated with higher prevaccination frequencies of total and inflammatory monocytes and higher CCR2 MFI, higher plasma sTNFR1 and CXCL-10 with higher LPS stimulated expression of TNFα and IL-6, concomitant with lower postvaccination influenza antibody titers. In HIV+ CD11b expressers, the depletion of inflammatory monocytes from PBMC resulted in enhanced antigen-specific CD4 T-cell proliferation. Immature CD56 natural killer cells were lower in young HIV+ compared with young HIV- participants.
[h=4]CONCLUSION:[/h] Perturbations of innate immunity and inflammation signified by high CD11b on inflammatory monocytes are exacerbated with aging in HIV+ and negatively impact immune function involved in Ab response to influenza vaccination.
PMID: 29683844 DOI: 10.1097/QAD.0000000000001821