tetano
Editor, Senior Moderator
Clin Appl Thromb Hemost
. Jan-Dec 2021;27:10760296211051712.
doi: 10.1177/10760296211051712.
Low Incidence of Symptomatic Thrombotic Events in Adult Patients Hospitalized with Coronavirus 19: A Retrospective Cohort Study
Marcelo G Vallone[SUP] 1 [/SUP], Carolina Vazquez[SUP] 1 2 [/SUP], Fernando A Chuliber[SUP] 1 [/SUP], Verónica Privitera[SUP] 1 [/SUP], Augusto Ferraris[SUP] 1 3 [/SUP], Ramiro F Cantarella[SUP] 1 [/SUP], María F Indo[SUP] 1 [/SUP], Diego M Sanchez Thomas[SUP] 1 [/SUP], Verónica A Peuchot[SUP] 1 4 [/SUP], Fernando J Vazquez[SUP] 1 4 [/SUP]
Affiliations
Abstract
Background: Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic, there have been many reports of increased incidence of venous thromboembolism and arterial events as a complication.
Objective: To determine the incidence of symptomatic thrombotic events (TEs) in patients hospitalized for SARS-CoV2 disease (coronavirus 19 [Covid-19]).
Methods: A retrospective single-center cohort study with adult patients with a positive reverse transcriptase-polymerase chain reaction (rt-PCR) for SARS-CoV2, included from the date of diagnosis of Covid-19 and followed for 90 days or until death.
Results: A total of 1621 patients were included in this study. The median age was 73 years (interquartile range[SUB]25th-75th[/SUB] [IQR] 53-87 years) and 57% (913) were female. Overall mortality was 21.6% (348). The overall incidence of symptomatic TEs within 90 days of diagnosis was 1.8% (30 of 1621) occurring in 28 patients, including an incidence of pulmonary embolism of 0.9% (15, 95% confidence interval [CI] 0.60%-1.6%), deep venous thrombosis of 0.61% (10, 95% CI 0.2%-1%), ischemic stroke of 0.25% (4, 95% CI 0.09%-0.65%), and ischemic arterial events of 0.06% (1, 95% CI 0.008%-0.43%). No acute coronary syndrome events were recorded. The incidence of symptomatic TEs was significantly lower in the general ward than in intensive care units (1.2% vs 5.7%; p < .001). The median time since positive rt-PCR for SARS-CoV2 to symptomatic TE was 22.5 days (IQR 19-43 days). There was no significant difference in the proportion of patients receiving (53.6%) and not receiving thromboprophylaxis (66.5%) and the development of TEs.
Conclusion: The overall incidence of symptomatic TEs among these patients was lower than the incidence previously reported.
Keywords: Covid 19; deep venous thrombosis; pulmonary embolism; thrombosis.
. Jan-Dec 2021;27:10760296211051712.
doi: 10.1177/10760296211051712.
Low Incidence of Symptomatic Thrombotic Events in Adult Patients Hospitalized with Coronavirus 19: A Retrospective Cohort Study
Marcelo G Vallone[SUP] 1 [/SUP], Carolina Vazquez[SUP] 1 2 [/SUP], Fernando A Chuliber[SUP] 1 [/SUP], Verónica Privitera[SUP] 1 [/SUP], Augusto Ferraris[SUP] 1 3 [/SUP], Ramiro F Cantarella[SUP] 1 [/SUP], María F Indo[SUP] 1 [/SUP], Diego M Sanchez Thomas[SUP] 1 [/SUP], Verónica A Peuchot[SUP] 1 4 [/SUP], Fernando J Vazquez[SUP] 1 4 [/SUP]
Affiliations
- PMID: 34714177
- DOI: 10.1177/10760296211051712
Abstract
Background: Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic, there have been many reports of increased incidence of venous thromboembolism and arterial events as a complication.
Objective: To determine the incidence of symptomatic thrombotic events (TEs) in patients hospitalized for SARS-CoV2 disease (coronavirus 19 [Covid-19]).
Methods: A retrospective single-center cohort study with adult patients with a positive reverse transcriptase-polymerase chain reaction (rt-PCR) for SARS-CoV2, included from the date of diagnosis of Covid-19 and followed for 90 days or until death.
Results: A total of 1621 patients were included in this study. The median age was 73 years (interquartile range[SUB]25th-75th[/SUB] [IQR] 53-87 years) and 57% (913) were female. Overall mortality was 21.6% (348). The overall incidence of symptomatic TEs within 90 days of diagnosis was 1.8% (30 of 1621) occurring in 28 patients, including an incidence of pulmonary embolism of 0.9% (15, 95% confidence interval [CI] 0.60%-1.6%), deep venous thrombosis of 0.61% (10, 95% CI 0.2%-1%), ischemic stroke of 0.25% (4, 95% CI 0.09%-0.65%), and ischemic arterial events of 0.06% (1, 95% CI 0.008%-0.43%). No acute coronary syndrome events were recorded. The incidence of symptomatic TEs was significantly lower in the general ward than in intensive care units (1.2% vs 5.7%; p < .001). The median time since positive rt-PCR for SARS-CoV2 to symptomatic TE was 22.5 days (IQR 19-43 days). There was no significant difference in the proportion of patients receiving (53.6%) and not receiving thromboprophylaxis (66.5%) and the development of TEs.
Conclusion: The overall incidence of symptomatic TEs among these patients was lower than the incidence previously reported.
Keywords: Covid 19; deep venous thrombosis; pulmonary embolism; thrombosis.