tetano
Editor, Senior Moderator
Clin Case Rep
. 2022 Mar 13;10(3):e05565.
doi: 10.1002/ccr3.5565. eCollection 2022 Mar.
Toxic Epidermal Necrolysis associated with COVID-19 infection: A case report
Lamia Jouhar[SUP] 1 [/SUP], Marva Yahya[SUP] 1 [/SUP], Sohair Elsiddiq[SUP] 1 [/SUP]
Affiliations
Abstract
Toxic Epidermal Necrolysis/Steven-Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID-19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) with a wide range of clinical manifestations. Skin involvement is common in COVID-19 patients including urticaria, purpura, and vasculitis. There were reported cases of TEN/SJS in adults with COVID-19 infections and only two reported cases in pediatric patients. The causality relationship between COVID-19 infection and TEN/SJS was not established in most cases due to history of drug usage that could be the trigger. In this study, we are reporting a case of previously healthy child apart from COVID-19 infection who was admitted to the intensive care unit with TEN involving more than 30% of body surface area confirmed by skin biopsy. The child was treated with intravenous immunoglobulins, steroids, and cyclosporin with a very good outcome.
Keywords: COVID‐19; dermatology; pediatrics; toxic epidermal necrolysis.
. 2022 Mar 13;10(3):e05565.
doi: 10.1002/ccr3.5565. eCollection 2022 Mar.
Toxic Epidermal Necrolysis associated with COVID-19 infection: A case report
Lamia Jouhar[SUP] 1 [/SUP], Marva Yahya[SUP] 1 [/SUP], Sohair Elsiddiq[SUP] 1 [/SUP]
Affiliations
- PMID: 35310321
- PMCID: PMC8918465
- DOI: 10.1002/ccr3.5565
Abstract
Toxic Epidermal Necrolysis/Steven-Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID-19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) with a wide range of clinical manifestations. Skin involvement is common in COVID-19 patients including urticaria, purpura, and vasculitis. There were reported cases of TEN/SJS in adults with COVID-19 infections and only two reported cases in pediatric patients. The causality relationship between COVID-19 infection and TEN/SJS was not established in most cases due to history of drug usage that could be the trigger. In this study, we are reporting a case of previously healthy child apart from COVID-19 infection who was admitted to the intensive care unit with TEN involving more than 30% of body surface area confirmed by skin biopsy. The child was treated with intravenous immunoglobulins, steroids, and cyclosporin with a very good outcome.
Keywords: COVID‐19; dermatology; pediatrics; toxic epidermal necrolysis.