tetano
Editor, Senior Moderator
Clin Chim Acta
. 2020 Jun 5;S0009-8981(20)30277-1.
doi: 10.1016/j.cca.2020.06.013. Online ahead of print.
C-reactive Protein: A Promising Biomarker for Poor Prognosis in COVID-19 Infection
Bikash R Sahu[SUP] 1 [/SUP], Raj Kishor Kampa[SUP] 2 [/SUP], Archana Padhi[SUP] 3 [/SUP], Aditya K Panda[SUP] 4 [/SUP]
Affiliations
Abstract
Background: The novel coronavirus disease 2019 (COVID-19) break out from Wuhan, China, spread over 227 countries and caused approximately 0.3 million death worldwide. Several biomolecules have been explored for possible biomarkers for prognosis outcome. Although increased C reactive protein (CRP) has been associated with death due to COVID-19 infections, results from different populations remain inconsistent. For a conclusive result, the present meta-analysis was performed.
Methods: We conducted a literature survey in PubMed and Scopus database for the association of CRP concentration with COVID-19 disease outcomes. A total of 16 eligible studies were enrolled in the present analysis comprising of 1896 survivors and 849 non-survivors cases. Concentrations of CRP were compared and analyzed by a meta-analysis.
Results: Egger's regression analysis (intercept=0.04, P=0.98, 95%CI=-5.48 to 5.58) and funnel plot revealed an absence of publication bias in the included studies. Due to the presence of significant heterogeneity across the studies (Q=252.03, P[SUB]heterogeneity[/SUB]= 0.000, I[SUP]2[/SUP]=93.65) random model was used for the analysis of the present study. The results of the meta-analysis demonstrated a significant role of CRP in COVID-19 infection outcome (Standard difference in means= 1.371, P=0.000).
Conclusions: Concentrations of CRP remained increased in patients who died in COVID-19 infection and could be a promising biomarker for accessing disease lethality.
Keywords: Biomarkers; COVID-19; CRP; Meta-analysis; Non-survivors; Survivors.
. 2020 Jun 5;S0009-8981(20)30277-1.
doi: 10.1016/j.cca.2020.06.013. Online ahead of print.
C-reactive Protein: A Promising Biomarker for Poor Prognosis in COVID-19 Infection
Bikash R Sahu[SUP] 1 [/SUP], Raj Kishor Kampa[SUP] 2 [/SUP], Archana Padhi[SUP] 3 [/SUP], Aditya K Panda[SUP] 4 [/SUP]
Affiliations
- PMID: 32511972
- PMCID: PMC7274122
- DOI: 10.1016/j.cca.2020.06.013
Abstract
Background: The novel coronavirus disease 2019 (COVID-19) break out from Wuhan, China, spread over 227 countries and caused approximately 0.3 million death worldwide. Several biomolecules have been explored for possible biomarkers for prognosis outcome. Although increased C reactive protein (CRP) has been associated with death due to COVID-19 infections, results from different populations remain inconsistent. For a conclusive result, the present meta-analysis was performed.
Methods: We conducted a literature survey in PubMed and Scopus database for the association of CRP concentration with COVID-19 disease outcomes. A total of 16 eligible studies were enrolled in the present analysis comprising of 1896 survivors and 849 non-survivors cases. Concentrations of CRP were compared and analyzed by a meta-analysis.
Results: Egger's regression analysis (intercept=0.04, P=0.98, 95%CI=-5.48 to 5.58) and funnel plot revealed an absence of publication bias in the included studies. Due to the presence of significant heterogeneity across the studies (Q=252.03, P[SUB]heterogeneity[/SUB]= 0.000, I[SUP]2[/SUP]=93.65) random model was used for the analysis of the present study. The results of the meta-analysis demonstrated a significant role of CRP in COVID-19 infection outcome (Standard difference in means= 1.371, P=0.000).
Conclusions: Concentrations of CRP remained increased in patients who died in COVID-19 infection and could be a promising biomarker for accessing disease lethality.
Keywords: Biomarkers; COVID-19; CRP; Meta-analysis; Non-survivors; Survivors.