tetano
Editor, Senior Moderator
Clin Epidemiol Glob Health
. Jan-Feb 2022;13:100971.
doi: 10.1016/j.cegh.2022.100971. Epub 2022 Jan 19.
A comparison of clinical outcomes between vaccinated and vaccine-naive patients of COVID-19, in four tertiary care hospitals of Kerala, South India
Sabarish Balachandran[SUP] 1 [/SUP], Merlin Moni[SUP] 2 [/SUP], Dipu T Sathyapalan[SUP] 2 [/SUP], Prinoj Varghese[SUP] 3 [/SUP], Manoj P Jose[SUP] 4 [/SUP], Mithun R Murugan[SUP] 5 [/SUP], C Rajan[SUP] 3 [/SUP], Dhanraj Saboo[SUP] 6 [/SUP], Sooraj S Nair[SUP] 7 [/SUP], Reshmi Ann Varkey[SUP] 8 [/SUP], Parvathy Balachandran[SUP] 9 [/SUP], Geetha R Menon[SUP] 10 [/SUP], Beena K Vasudevan[SUP] 8 [/SUP], Amitava Banerjee[SUP] 11 [/SUP], Chandrasekhar Janakiram[SUP] 9 [/SUP], Jaideep C Menon[SUP] 12 [/SUP]
Affiliations
Abstract
The problem considered: This multi-centric study analyzed data of COVID-19 patients and compared differences in symptomatology, management, and outcomes between vaccinated and vaccine-naive patients.
Methods: All COVID-19 positive individuals treated as an in-or out-patient from the 1[SUP]st[/SUP]March to 15[SUP]th[/SUP] May 2021 in four selected study sites were considered for the study. Treatment details, symptoms, and clinical course were obtained from hospital records. Chi-square was used to test the association of socio-demographic and treatment variables with the vaccination status and binary logistic regression were used to obtain the odds ratio with a 95% confidence interval.
Results: The analysis was of 1446 patients after exclusion of 156 with missing data of which males were 57.3% and females 42.7%. 346 were vaccinated; 189 received one dose and 157 both doses. Hospitalization was more in vaccinated (38.2% vs 27.4%); ICU admissions were less in vaccinated (3.5% vs 7.1%). More vaccinated were symptomatic (OR = 1.5); half less likely to be on non-invasive ventilation (OR = 0.5) while vaccine naive patients had 4.21 times the risk of death.
Conclusion: Severe infection, duration of hospital stays, need for ventilation and death were significantly less among vaccinated when compared with vaccine naive patients.
Keywords: COVID-19; Coronavirus; Outcomes; Vaccine; Vaccine-breakthrough infection.
. Jan-Feb 2022;13:100971.
doi: 10.1016/j.cegh.2022.100971. Epub 2022 Jan 19.
A comparison of clinical outcomes between vaccinated and vaccine-naive patients of COVID-19, in four tertiary care hospitals of Kerala, South India
Sabarish Balachandran[SUP] 1 [/SUP], Merlin Moni[SUP] 2 [/SUP], Dipu T Sathyapalan[SUP] 2 [/SUP], Prinoj Varghese[SUP] 3 [/SUP], Manoj P Jose[SUP] 4 [/SUP], Mithun R Murugan[SUP] 5 [/SUP], C Rajan[SUP] 3 [/SUP], Dhanraj Saboo[SUP] 6 [/SUP], Sooraj S Nair[SUP] 7 [/SUP], Reshmi Ann Varkey[SUP] 8 [/SUP], Parvathy Balachandran[SUP] 9 [/SUP], Geetha R Menon[SUP] 10 [/SUP], Beena K Vasudevan[SUP] 8 [/SUP], Amitava Banerjee[SUP] 11 [/SUP], Chandrasekhar Janakiram[SUP] 9 [/SUP], Jaideep C Menon[SUP] 12 [/SUP]
Affiliations
- PMID: 35075439
- PMCID: PMC8769674
- DOI: 10.1016/j.cegh.2022.100971
Abstract
The problem considered: This multi-centric study analyzed data of COVID-19 patients and compared differences in symptomatology, management, and outcomes between vaccinated and vaccine-naive patients.
Methods: All COVID-19 positive individuals treated as an in-or out-patient from the 1[SUP]st[/SUP]March to 15[SUP]th[/SUP] May 2021 in four selected study sites were considered for the study. Treatment details, symptoms, and clinical course were obtained from hospital records. Chi-square was used to test the association of socio-demographic and treatment variables with the vaccination status and binary logistic regression were used to obtain the odds ratio with a 95% confidence interval.
Results: The analysis was of 1446 patients after exclusion of 156 with missing data of which males were 57.3% and females 42.7%. 346 were vaccinated; 189 received one dose and 157 both doses. Hospitalization was more in vaccinated (38.2% vs 27.4%); ICU admissions were less in vaccinated (3.5% vs 7.1%). More vaccinated were symptomatic (OR = 1.5); half less likely to be on non-invasive ventilation (OR = 0.5) while vaccine naive patients had 4.21 times the risk of death.
Conclusion: Severe infection, duration of hospital stays, need for ventilation and death were significantly less among vaccinated when compared with vaccine naive patients.
Keywords: COVID-19; Coronavirus; Outcomes; Vaccine; Vaccine-breakthrough infection.