tetano
Editor, Senior Moderator
Clin Epidemiol Glob Health
. May-Jun 2022;15:101059.
doi: 10.1016/j.cegh.2022.101059. Epub 2022 May 8.
Differences in inflammatory markers between coronavirus disease 2019 and sepsis in hospitalised patients
Nery E Linarez Ochoa[SUP] 1 2 [/SUP], Gaspar Rodríguez[SUP] 2 3 [/SUP], Irma Dolores Reyes[SUP] 1 2 [/SUP], Karla M Rico Rivas[SUP] 1 [/SUP], Celeo Ramírez[SUP] 2 4 [/SUP], Reyna M Durón[SUP] 5 [/SUP]
Affiliations
Abstract
Background: Inflammatory markers are pivotal for the diagnosis of coronavirus disease 2019 (COVID-19) and sepsis. This study compared markers between hospitalised patients with COVID-19 and those with bacterial sepsis.
Methods: This retrospective single-centre cohort study included 50 patients with COVID-19 clinical stages II and III and 24 patients with bacterial sepsis. Both groups were treated according to the country's official standards. Leukocytes, C-reactive protein (CRP), ferritin, and D-dimer were registered at the time of patient's admission and 24, 48, and 72 h after initiating intrahospital treatment.
Results: Upon admission, marker levels were high, with a significant decrease at 72 h after antibiotic therapy in the sepsis group. The leukocyte count was higher in deceased patients with sepsis. The mean ferritin levels were 1105 mcg/dl for COVID-19 and 525 mcg/dL for sepsis. Higher ferritin levels in COVID-19 (P = 0.001) seemed to be a predictor of higher mortality. Upon admission, the median D-dimer level was 0.68 mg/L for COVID-19 and 3 mg/L for patients with sepsis, whether recovered or deceased. As D-dimer, procalcitonin levels were higher in patients with sepsis (P = 0.001). CRP levels were equally elevated in both entities but higher in deceased patients with COVID-19.
Conclusion: Ferritin was the main inflammatory marker for COVID-19, and leukocytes, procalcitonin, and D-dimer were the main markers of sepsis. Markers that were most affected in deceased patients were CRP for COVID-19 and leukocyte for sepsis. The therapeutic implications of these differences require further study.
Keywords: Biomarkers; Pneumonia; SARS-CoV-2 infection; Sepsis; Viral.
. May-Jun 2022;15:101059.
doi: 10.1016/j.cegh.2022.101059. Epub 2022 May 8.
Differences in inflammatory markers between coronavirus disease 2019 and sepsis in hospitalised patients
Nery E Linarez Ochoa[SUP] 1 2 [/SUP], Gaspar Rodríguez[SUP] 2 3 [/SUP], Irma Dolores Reyes[SUP] 1 2 [/SUP], Karla M Rico Rivas[SUP] 1 [/SUP], Celeo Ramírez[SUP] 2 4 [/SUP], Reyna M Durón[SUP] 5 [/SUP]
Affiliations
- PMID: 35574431
- PMCID: PMC9080673
- DOI: 10.1016/j.cegh.2022.101059
Abstract
Background: Inflammatory markers are pivotal for the diagnosis of coronavirus disease 2019 (COVID-19) and sepsis. This study compared markers between hospitalised patients with COVID-19 and those with bacterial sepsis.
Methods: This retrospective single-centre cohort study included 50 patients with COVID-19 clinical stages II and III and 24 patients with bacterial sepsis. Both groups were treated according to the country's official standards. Leukocytes, C-reactive protein (CRP), ferritin, and D-dimer were registered at the time of patient's admission and 24, 48, and 72 h after initiating intrahospital treatment.
Results: Upon admission, marker levels were high, with a significant decrease at 72 h after antibiotic therapy in the sepsis group. The leukocyte count was higher in deceased patients with sepsis. The mean ferritin levels were 1105 mcg/dl for COVID-19 and 525 mcg/dL for sepsis. Higher ferritin levels in COVID-19 (P = 0.001) seemed to be a predictor of higher mortality. Upon admission, the median D-dimer level was 0.68 mg/L for COVID-19 and 3 mg/L for patients with sepsis, whether recovered or deceased. As D-dimer, procalcitonin levels were higher in patients with sepsis (P = 0.001). CRP levels were equally elevated in both entities but higher in deceased patients with COVID-19.
Conclusion: Ferritin was the main inflammatory marker for COVID-19, and leukocytes, procalcitonin, and D-dimer were the main markers of sepsis. Markers that were most affected in deceased patients were CRP for COVID-19 and leukocyte for sepsis. The therapeutic implications of these differences require further study.
Keywords: Biomarkers; Pneumonia; SARS-CoV-2 infection; Sepsis; Viral.