tetano
Editor, Senior Moderator
Clin Exp Nephrol
. 2021 Nov 13.
doi: 10.1007/s10157-021-02157-x. Online ahead of print.
Gross hematuria after SARS-CoV-2 vaccination: questionnaire survey in Japan
Keiichi Matsuzaki[SUP] 1 2 [/SUP], Ryousuke Aoki[SUP] 1 3 [/SUP], Yoshihito Nihei[SUP] 1 3 [/SUP], Hitoshi Suzuki[SUP] 1 3 [/SUP], Masao Kihara[SUP] 1 3 [/SUP], Takashi Yokoo[SUP] 1 4 [/SUP], Naoki Kashihara[SUP] 1 5 [/SUP], Ichiei Narita[SUP] 1 6 [/SUP], Yusuke Suzuki[SUP] 7 8 9 [/SUP]
Affiliations
Abstract
Background: Recent clinical reports indicate a correlation between gross hematuria after the coronavirus 2019 (COVID-19) vaccination in patients with glomerulonephritis, especially immunoglobulin A nephropathy (IgAN). Furthermore, healthcare workers in Japan were initially vaccinated with an mRNA vaccine from February 17, 2021, and some of them experienced gross hematuria after receiving the vaccination.
Methods: We conducted a web-based survey of the councilor members of the Japanese Society of Nephrology (581 members, 382 facilities) to elucidate the relationship between gross hematuria and COVID-19 vaccination.
Results: In the first survey, 27 cases (female: 22, 81.5%) of gross hematuria were reported after receiving a COVID-19 vaccination. Of them, 19 (70.4%) patients were already diagnosed with IgAN at the occurrence of gross hematuria. Proteinuria appeared in eight of the 14 (57.1%) cases with no proteinuria before vaccination and hematuria in five of the seven (71.4%) cases with no hematuria before vaccination. The second survey revealed that a renal biopsy was performed after vaccination in four cases, all of whom were diagnosed with IgAN. Only one case showed a slightly increased serum creatinine level, and no patients progressed to severe renal dysfunction.
Conclusion: This study clarified the clinical features of gross hematuria after a COVID-19 vaccination. Because there was no obvious progression to severe renal dysfunction, safety of the COVID-19 vaccination is warranted at least in the protocol of inoculation twice.
Keywords: Coronavirus 2019; Gross hematuria; IgA nephropathy; SARS-CoV-2 vaccination; mRNA vaccination.
. 2021 Nov 13.
doi: 10.1007/s10157-021-02157-x. Online ahead of print.
Gross hematuria after SARS-CoV-2 vaccination: questionnaire survey in Japan
Keiichi Matsuzaki[SUP] 1 2 [/SUP], Ryousuke Aoki[SUP] 1 3 [/SUP], Yoshihito Nihei[SUP] 1 3 [/SUP], Hitoshi Suzuki[SUP] 1 3 [/SUP], Masao Kihara[SUP] 1 3 [/SUP], Takashi Yokoo[SUP] 1 4 [/SUP], Naoki Kashihara[SUP] 1 5 [/SUP], Ichiei Narita[SUP] 1 6 [/SUP], Yusuke Suzuki[SUP] 7 8 9 [/SUP]
Affiliations
- PMID: 34773533
- DOI: 10.1007/s10157-021-02157-x
Abstract
Background: Recent clinical reports indicate a correlation between gross hematuria after the coronavirus 2019 (COVID-19) vaccination in patients with glomerulonephritis, especially immunoglobulin A nephropathy (IgAN). Furthermore, healthcare workers in Japan were initially vaccinated with an mRNA vaccine from February 17, 2021, and some of them experienced gross hematuria after receiving the vaccination.
Methods: We conducted a web-based survey of the councilor members of the Japanese Society of Nephrology (581 members, 382 facilities) to elucidate the relationship between gross hematuria and COVID-19 vaccination.
Results: In the first survey, 27 cases (female: 22, 81.5%) of gross hematuria were reported after receiving a COVID-19 vaccination. Of them, 19 (70.4%) patients were already diagnosed with IgAN at the occurrence of gross hematuria. Proteinuria appeared in eight of the 14 (57.1%) cases with no proteinuria before vaccination and hematuria in five of the seven (71.4%) cases with no hematuria before vaccination. The second survey revealed that a renal biopsy was performed after vaccination in four cases, all of whom were diagnosed with IgAN. Only one case showed a slightly increased serum creatinine level, and no patients progressed to severe renal dysfunction.
Conclusion: This study clarified the clinical features of gross hematuria after a COVID-19 vaccination. Because there was no obvious progression to severe renal dysfunction, safety of the COVID-19 vaccination is warranted at least in the protocol of inoculation twice.
Keywords: Coronavirus 2019; Gross hematuria; IgA nephropathy; SARS-CoV-2 vaccination; mRNA vaccination.