tetano
Editor, Senior Moderator
Clin Exp Nephrol
. 2021 Sep 6.
doi: 10.1007/s10157-021-02130-8. Online ahead of print.
Hemodialysis patients with coronavirus disease 2019: reduced antibody response
Hiroko Beppu[SUP] 1 [/SUP], Tatsuya Fukuda[SUP] 2 3 [/SUP], Tomoko Kawanishi[SUP] 1 [/SUP], Fumihiko Yasui[SUP] 4 [/SUP], Minami Toda[SUP] 1 [/SUP], Hitomi Kimura[SUP] 1 [/SUP], Yuki Nakamura[SUP] 1 [/SUP], Yuka Nakamura[SUP] 1 [/SUP], Kaori Kojima[SUP] 1 [/SUP], Hina Ogawa[SUP] 1 [/SUP], Ayumi Ishiwatari[SUP] 1 [/SUP], Yuiko Kamei[SUP] 1 [/SUP], Toshie Ogawa[SUP] 1 [/SUP], Yasutomo Abe[SUP] 1 [/SUP], Mariko Endo[SUP] 1 [/SUP], Tomohide Hanawa[SUP] 5 [/SUP], Rie Mizobuchi[SUP] 5 [/SUP], Chise Sugita[SUP] 5 [/SUP], Koh Okamoto[SUP] 5 6 [/SUP], Shuji Hatakeyama[SUP] 5 7 [/SUP], Tetsusya Yamada[SUP] 8 [/SUP], Michinori Kohara[SUP] 4 [/SUP], Sachiko Wakai[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Because patients on maintenance hemodialysis (HD) have an impaired immune response to pathogens, they are at higher risk of severe coronavirus disease 2019 (COVID-19). However, data on antibody production among HD patients with COVID-19 is scarce. Thus, we performed a retrospective cohort study evaluating severe acute respiratory syndrome coronavirus two antibody (SARS-CoV-2) production within 1 month after COVID-19 onset in hospitalized patients on HD.
Methods: SARS-CoV-2-specific immunoglobulin (Ig) G levels were quantified using an iFlash 3000 Chemiluminescence Immunoassay analyzer (Shenzhen YHLO Biotech Co., Ltd.) to detect IgG antibodies specific for the S1 subunit of the spike protein (IgG-S1). Propensity score matching was used to balance covariate distribution in HD and non-HD patients. From April 2020 to February 2021, antibody testing was performed on 161 hospitalized patients with symptomatic COVID-19. Of them, 34 HD patients were matched to 68 non-HD patients.
Results: After propensity score matching, the median levels of IgG-S1 in the HD patients at 7-13 days after symptom onset were significantly lower than in non-HD patients, especially in those with severe disease. Among all patients, those with severe disease produced lower levels of IgG-S1 at 7-13 days compared with non-severe patients.
Conclusion: COVID-19 patients with severe disease, especially those undergoing HD, had lower IgG-S1 production in the second week of the disease. Thus, the increased risk of severe COVID-19 in HD patients may be, in part, due to a slow and reduced antibody response.
Keywords: Antibody; COVID-19; Hemodialysis; Immune response; SARS-CoV-2; Severe disease.
. 2021 Sep 6.
doi: 10.1007/s10157-021-02130-8. Online ahead of print.
Hemodialysis patients with coronavirus disease 2019: reduced antibody response
Hiroko Beppu[SUP] 1 [/SUP], Tatsuya Fukuda[SUP] 2 3 [/SUP], Tomoko Kawanishi[SUP] 1 [/SUP], Fumihiko Yasui[SUP] 4 [/SUP], Minami Toda[SUP] 1 [/SUP], Hitomi Kimura[SUP] 1 [/SUP], Yuki Nakamura[SUP] 1 [/SUP], Yuka Nakamura[SUP] 1 [/SUP], Kaori Kojima[SUP] 1 [/SUP], Hina Ogawa[SUP] 1 [/SUP], Ayumi Ishiwatari[SUP] 1 [/SUP], Yuiko Kamei[SUP] 1 [/SUP], Toshie Ogawa[SUP] 1 [/SUP], Yasutomo Abe[SUP] 1 [/SUP], Mariko Endo[SUP] 1 [/SUP], Tomohide Hanawa[SUP] 5 [/SUP], Rie Mizobuchi[SUP] 5 [/SUP], Chise Sugita[SUP] 5 [/SUP], Koh Okamoto[SUP] 5 6 [/SUP], Shuji Hatakeyama[SUP] 5 7 [/SUP], Tetsusya Yamada[SUP] 8 [/SUP], Michinori Kohara[SUP] 4 [/SUP], Sachiko Wakai[SUP] 1 [/SUP]
Affiliations
- PMID: 34487276
- DOI: 10.1007/s10157-021-02130-8
Abstract
Background: Because patients on maintenance hemodialysis (HD) have an impaired immune response to pathogens, they are at higher risk of severe coronavirus disease 2019 (COVID-19). However, data on antibody production among HD patients with COVID-19 is scarce. Thus, we performed a retrospective cohort study evaluating severe acute respiratory syndrome coronavirus two antibody (SARS-CoV-2) production within 1 month after COVID-19 onset in hospitalized patients on HD.
Methods: SARS-CoV-2-specific immunoglobulin (Ig) G levels were quantified using an iFlash 3000 Chemiluminescence Immunoassay analyzer (Shenzhen YHLO Biotech Co., Ltd.) to detect IgG antibodies specific for the S1 subunit of the spike protein (IgG-S1). Propensity score matching was used to balance covariate distribution in HD and non-HD patients. From April 2020 to February 2021, antibody testing was performed on 161 hospitalized patients with symptomatic COVID-19. Of them, 34 HD patients were matched to 68 non-HD patients.
Results: After propensity score matching, the median levels of IgG-S1 in the HD patients at 7-13 days after symptom onset were significantly lower than in non-HD patients, especially in those with severe disease. Among all patients, those with severe disease produced lower levels of IgG-S1 at 7-13 days compared with non-severe patients.
Conclusion: COVID-19 patients with severe disease, especially those undergoing HD, had lower IgG-S1 production in the second week of the disease. Thus, the increased risk of severe COVID-19 in HD patients may be, in part, due to a slow and reduced antibody response.
Keywords: Antibody; COVID-19; Hemodialysis; Immune response; SARS-CoV-2; Severe disease.