tetano
Editor, Senior Moderator
Clin Exp Vaccine Res
. 2024 Jan;13(1):68-71.
doi: 10.7774/cevr.2024.13.1.68. Epub 2024 Jan 31. Acute interstitial nephritis with acute kidney injury after COVID-19 vaccination: a case report
Jimin Lim[SUP] 1 [/SUP], Jin Hyuk Paek[SUP] 1 2 [/SUP], Hyeong Chan Shin[SUP] 3 [/SUP], Woo Yeong Park[SUP] 1 2 [/SUP], Kyubok Jin[SUP] 1 2 [/SUP], Misun Choe[SUP] 3 [/SUP], Seungyeup Han[SUP] 1 2 [/SUP], Yaerim Kim[SUP] 1 2 [/SUP]
Affiliations
In the context of the massive spread of coronavirus disease 2019 (COVID-19), the development of a COVID-19 vaccine is urgently needed. The Pfizer-BioNTech COVID-19 vaccine has been widely applied across global populations. Herein, we report a case of acute interstitial nephritis with acute kidney injury in a young healthy subject after administration of the COVID-19 vaccine. A 20-year-old man was admitted with abdominal discomfort and nausea. He had received the Pfizer-BioNTech COVID-19 vaccine 6 days before. At 9 days after vaccination, his kidney function was decreased, with serum creatinine levels of 1.8 mg/dL. Even with supportive care with hydration, his kidney function worsened, and he underwent a kidney biopsy. The pathology findings revealed diffuse interstitial infiltration of inflammatory cells, predominantly comprising lymphocytes, with preservation of the glomerulus. No abnormal findings were noted by immunofluorescence or electron microscopy. Based on a diagnosis of drug-related acute interstitial nephritis, we treated the patient with high-dose prednisolone. After administration of prednisolone, kidney function slowly improved. A close linkage between COVID-19 vaccination and acute interstitial nephritis should be considered in the clinic, despite the low incidence.
Keywords: Acute kidney injury; COVID-19; Case report; Interstitial nephritis; Vaccination.
. 2024 Jan;13(1):68-71.
doi: 10.7774/cevr.2024.13.1.68. Epub 2024 Jan 31. Acute interstitial nephritis with acute kidney injury after COVID-19 vaccination: a case report
Jimin Lim[SUP] 1 [/SUP], Jin Hyuk Paek[SUP] 1 2 [/SUP], Hyeong Chan Shin[SUP] 3 [/SUP], Woo Yeong Park[SUP] 1 2 [/SUP], Kyubok Jin[SUP] 1 2 [/SUP], Misun Choe[SUP] 3 [/SUP], Seungyeup Han[SUP] 1 2 [/SUP], Yaerim Kim[SUP] 1 2 [/SUP]
Affiliations
- PMID: 38362370
- PMCID: PMC10864883
- DOI: 10.7774/cevr.2024.13.1.68
In the context of the massive spread of coronavirus disease 2019 (COVID-19), the development of a COVID-19 vaccine is urgently needed. The Pfizer-BioNTech COVID-19 vaccine has been widely applied across global populations. Herein, we report a case of acute interstitial nephritis with acute kidney injury in a young healthy subject after administration of the COVID-19 vaccine. A 20-year-old man was admitted with abdominal discomfort and nausea. He had received the Pfizer-BioNTech COVID-19 vaccine 6 days before. At 9 days after vaccination, his kidney function was decreased, with serum creatinine levels of 1.8 mg/dL. Even with supportive care with hydration, his kidney function worsened, and he underwent a kidney biopsy. The pathology findings revealed diffuse interstitial infiltration of inflammatory cells, predominantly comprising lymphocytes, with preservation of the glomerulus. No abnormal findings were noted by immunofluorescence or electron microscopy. Based on a diagnosis of drug-related acute interstitial nephritis, we treated the patient with high-dose prednisolone. After administration of prednisolone, kidney function slowly improved. A close linkage between COVID-19 vaccination and acute interstitial nephritis should be considered in the clinic, despite the low incidence.
Keywords: Acute kidney injury; COVID-19; Case report; Interstitial nephritis; Vaccination.