tetano
Editor, Senior Moderator
Clin Exp Vaccine Res
. 2024 Jul;13(3):225-231.
doi: 10.7774/cevr.2024.13.3.225. Epub 2024 Jul 31. SARS-CoV-2 parental vaccination and risk of multisystem inflammatory syndrome in children: a single-center retrospective study
Raffaele Falsaperla[SUP] 1 2 3 [/SUP], Vincenzo Sortino[SUP] 2 [/SUP], Ausilia Desiree Collotta[SUP] 2 4 [/SUP], Patrizia Grassi[SUP] 5 [/SUP], Marco Simone Vaccalluzzo[SUP] 6 [/SUP], Alfredo Pulvirenti[SUP] 7 [/SUP], Francesco Gambilonghi[SUP] 4 [/SUP], Martino Ruggieri[SUP] 8 [/SUP]
Affiliations
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children.
Materials and methods: Our retrospective single center study included 124 patients aged 1 month to 18 years admitted to emergency department from April 2020 to March 2022 for coronavirus disease 2019 disease.
Results: Parental vaccination was negatively correlated with the development of MIS-C: 4% of patients with both parents vaccinated developed MIS-C, while patients with no parent vaccinated to have developed MIS-C were 20%.
Conclusion: Parental vaccination could be an important factor influencing the course of the disease and reduces the probability that a child would develop MIS-C by 83% if both parents vaccinated.
Keywords: Multisystem inflammatory syndrome in children; Pediatric COVID-19; SARS-CoV-2 infection; SARS-CoV-2 vaccination.
. 2024 Jul;13(3):225-231.
doi: 10.7774/cevr.2024.13.3.225. Epub 2024 Jul 31. SARS-CoV-2 parental vaccination and risk of multisystem inflammatory syndrome in children: a single-center retrospective study
Raffaele Falsaperla[SUP] 1 2 3 [/SUP], Vincenzo Sortino[SUP] 2 [/SUP], Ausilia Desiree Collotta[SUP] 2 4 [/SUP], Patrizia Grassi[SUP] 5 [/SUP], Marco Simone Vaccalluzzo[SUP] 6 [/SUP], Alfredo Pulvirenti[SUP] 7 [/SUP], Francesco Gambilonghi[SUP] 4 [/SUP], Martino Ruggieri[SUP] 8 [/SUP]
Affiliations
- PMID: 39144126
- PMCID: PMC11319114
- DOI: 10.7774/cevr.2024.13.3.225
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children.
Materials and methods: Our retrospective single center study included 124 patients aged 1 month to 18 years admitted to emergency department from April 2020 to March 2022 for coronavirus disease 2019 disease.
Results: Parental vaccination was negatively correlated with the development of MIS-C: 4% of patients with both parents vaccinated developed MIS-C, while patients with no parent vaccinated to have developed MIS-C were 20%.
Conclusion: Parental vaccination could be an important factor influencing the course of the disease and reduces the probability that a child would develop MIS-C by 83% if both parents vaccinated.
Keywords: Multisystem inflammatory syndrome in children; Pediatric COVID-19; SARS-CoV-2 infection; SARS-CoV-2 vaccination.