tetano
Editor, Senior Moderator
Clin Infect Dis
. 2021 Nov 30;ciab938.
doi: 10.1093/cid/ciab938. Online ahead of print.
A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval
Brian Grunau[SUP] 1 2 3 [/SUP], Michael Asamoah-Boaheng[SUP] 2 4 [/SUP], Pascal M Lavoie[SUP] 5 [/SUP], Mohammad Ehsanul Karim[SUP] 1 6 [/SUP], Tracy L Kirkham[SUP] 7 8 [/SUP], Paul A Demers[SUP] 6 7 8 [/SUP], Vilte Barakauskas[SUP] 9 [/SUP], Ana Citlali Marquez[SUP] 9 10 [/SUP], Agatha N Jassem[SUP] 9 10 [/SUP], Sheila F O'Brien[SUP] 11 [/SUP], Steven J Drews[SUP] 11 12 [/SUP], Scott Haig[SUP] 3 [/SUP], Sheldon Cheskes[SUP] 13 [/SUP], David M Goldfarb[SUP] 9 [/SUP]
Affiliations
Abstract
The optimal dosing interval for severe acute respiratory syndrome coronavirus 2 vaccines remains controversial. In this prospective study, we compared serology results of paramedics vaccinated with mRNA vaccines at the recommended short (17-28 days) vs long (42-49 days) interval. We found that a long dosing interval resulted in higher spike, receptor binding domain, and spike N terminal domain antibody concentrations.
Keywords: COVID-19; SARS-CoV-2; antibodies; spike; vaccine.
. 2021 Nov 30;ciab938.
doi: 10.1093/cid/ciab938. Online ahead of print.
A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval
Brian Grunau[SUP] 1 2 3 [/SUP], Michael Asamoah-Boaheng[SUP] 2 4 [/SUP], Pascal M Lavoie[SUP] 5 [/SUP], Mohammad Ehsanul Karim[SUP] 1 6 [/SUP], Tracy L Kirkham[SUP] 7 8 [/SUP], Paul A Demers[SUP] 6 7 8 [/SUP], Vilte Barakauskas[SUP] 9 [/SUP], Ana Citlali Marquez[SUP] 9 10 [/SUP], Agatha N Jassem[SUP] 9 10 [/SUP], Sheila F O'Brien[SUP] 11 [/SUP], Steven J Drews[SUP] 11 12 [/SUP], Scott Haig[SUP] 3 [/SUP], Sheldon Cheskes[SUP] 13 [/SUP], David M Goldfarb[SUP] 9 [/SUP]
Affiliations
- PMID: 34849655
- DOI: 10.1093/cid/ciab938
Abstract
The optimal dosing interval for severe acute respiratory syndrome coronavirus 2 vaccines remains controversial. In this prospective study, we compared serology results of paramedics vaccinated with mRNA vaccines at the recommended short (17-28 days) vs long (42-49 days) interval. We found that a long dosing interval resulted in higher spike, receptor binding domain, and spike N terminal domain antibody concentrations.
Keywords: COVID-19; SARS-CoV-2; antibodies; spike; vaccine.