tetano
Editor, Senior Moderator
Clin Infect Dis
. 2024 Aug 19:ciae416.
doi: 10.1093/cid/ciae416. Online ahead of print. Association between SARS-CoV-2 infection during pregnancy and gestational diabetes: a claims-based cohort study
Oscar Rincón-Guevara[SUP] 1 [/SUP], Bailey Wallace[SUP] 2 [/SUP], Lyudmyla Kompaniyets[SUP] 3 [/SUP], Catherine E Barrett[SUP] 4 [/SUP], Lara Bull-Otterson[SUP] 5 [/SUP]
Affiliations
Introduction: Coronavirus disease 2019 (COVID-19) may be associated with gestational diabetes mellitus (GDM); however, evidence is limited by sample sizes and lack of control groups.
Methods: To assess the GDM risk after COVID-19 in pregnancy, we constructed a retrospective cohort of pregnancies ending March 2020-October 2022 using medical claims. People with COVID-19 diagnosis claims from conception to 21 gestational weeks (n = 57,675) were matched 1:2 to those without COVID-19 during pregnancy (n =115,350) by age-range, pregnancy start month, and encounter year-month. GDM (claim ≥23 gestational weeks) relative risk and risk difference overall, by race and ethnicity, and variant period were estimated using log-binomial models.
Results: GDM risk was higher among those with COVID-19 during pregnancy compared to those without (adjusted risk ratio, aRR = 1.12, 95% CI: 1.08-1.15). GDM risk was significantly associated with COVID-19 in non-Hispanic (NH) White (aRR = 1.08, 95% CI: 1.04-1.14), NH Black (aRR=1.15, 95% CI: 1.07-1.24), and Hispanic (aRR = 1.17, 95% CI: 1.10-1.24) groups. GDM risk was significantly higher during pre-Delta (aRR = 1.17, 95% CI: 1.11-1.24) as compared to Omicron (aRR = 1.07, 95% CI: 1.02-1.13) periods, but neither differed from the Delta period (aRR = 1.10, 95% CI: 1.04-1.17). The adjusted risk difference was 0-2% for all models.
Conclusions: COVID-19 during pregnancy was modestly associated with GDM in claims-based data, especially during earlier SARS-CoV-2 variant periods. As these associations are based on COVID-19 in claims data, studies employing systematic testing are warranted.
Keywords: COVID-19; gestational diabetes mellitus; medical claims; pregnancy; variant period.
. 2024 Aug 19:ciae416.
doi: 10.1093/cid/ciae416. Online ahead of print. Association between SARS-CoV-2 infection during pregnancy and gestational diabetes: a claims-based cohort study
Oscar Rincón-Guevara[SUP] 1 [/SUP], Bailey Wallace[SUP] 2 [/SUP], Lyudmyla Kompaniyets[SUP] 3 [/SUP], Catherine E Barrett[SUP] 4 [/SUP], Lara Bull-Otterson[SUP] 5 [/SUP]
Affiliations
- PMID: 39162200
- DOI: 10.1093/cid/ciae416
Introduction: Coronavirus disease 2019 (COVID-19) may be associated with gestational diabetes mellitus (GDM); however, evidence is limited by sample sizes and lack of control groups.
Methods: To assess the GDM risk after COVID-19 in pregnancy, we constructed a retrospective cohort of pregnancies ending March 2020-October 2022 using medical claims. People with COVID-19 diagnosis claims from conception to 21 gestational weeks (n = 57,675) were matched 1:2 to those without COVID-19 during pregnancy (n =115,350) by age-range, pregnancy start month, and encounter year-month. GDM (claim ≥23 gestational weeks) relative risk and risk difference overall, by race and ethnicity, and variant period were estimated using log-binomial models.
Results: GDM risk was higher among those with COVID-19 during pregnancy compared to those without (adjusted risk ratio, aRR = 1.12, 95% CI: 1.08-1.15). GDM risk was significantly associated with COVID-19 in non-Hispanic (NH) White (aRR = 1.08, 95% CI: 1.04-1.14), NH Black (aRR=1.15, 95% CI: 1.07-1.24), and Hispanic (aRR = 1.17, 95% CI: 1.10-1.24) groups. GDM risk was significantly higher during pre-Delta (aRR = 1.17, 95% CI: 1.11-1.24) as compared to Omicron (aRR = 1.07, 95% CI: 1.02-1.13) periods, but neither differed from the Delta period (aRR = 1.10, 95% CI: 1.04-1.17). The adjusted risk difference was 0-2% for all models.
Conclusions: COVID-19 during pregnancy was modestly associated with GDM in claims-based data, especially during earlier SARS-CoV-2 variant periods. As these associations are based on COVID-19 in claims data, studies employing systematic testing are warranted.
Keywords: COVID-19; gestational diabetes mellitus; medical claims; pregnancy; variant period.