tetano
Editor, Senior Moderator
Clin Infect Dis
. 2021 Mar 2;ciab198.
doi: 10.1093/cid/ciab198. Online ahead of print.
Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 virus variant with novel genomic architecture in Hong Kong
Herman Tse[SUP] 1 [/SUP], David Christopher Lung[SUP] 1 2 [/SUP], Sally Cheuk-Ying Wong[SUP] 1 [/SUP], Ka-Fai Ip[SUP] 1 [/SUP], Tak-Chiu Wu[SUP] 3 [/SUP], Kelvin Kai-Wang To[SUP] 4 5 [/SUP], Kin-Hang Kok[SUP] 4 5 [/SUP], Kwok-Yung Yuen[SUP] 4 5 [/SUP], Garnet Kwan-Yue Choi[SUP] 1 [/SUP]
Affiliations
Abstract
Throughout the COVID-19 pandemic, divergent SARS-CoV-2 lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b and ORF8, and a C-terminally modified ORF6 product resulting from partial 5'-UTR duplication and transposition.
Keywords: COVID-19; SARS-CoV-2; genomic rearrangement; whole-genome sequencing.
. 2021 Mar 2;ciab198.
doi: 10.1093/cid/ciab198. Online ahead of print.
Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 virus variant with novel genomic architecture in Hong Kong
Herman Tse[SUP] 1 [/SUP], David Christopher Lung[SUP] 1 2 [/SUP], Sally Cheuk-Ying Wong[SUP] 1 [/SUP], Ka-Fai Ip[SUP] 1 [/SUP], Tak-Chiu Wu[SUP] 3 [/SUP], Kelvin Kai-Wang To[SUP] 4 5 [/SUP], Kin-Hang Kok[SUP] 4 5 [/SUP], Kwok-Yung Yuen[SUP] 4 5 [/SUP], Garnet Kwan-Yue Choi[SUP] 1 [/SUP]
Affiliations
- PMID: 33675655
- DOI: 10.1093/cid/ciab198
Abstract
Throughout the COVID-19 pandemic, divergent SARS-CoV-2 lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b and ORF8, and a C-terminally modified ORF6 product resulting from partial 5'-UTR duplication and transposition.
Keywords: COVID-19; SARS-CoV-2; genomic rearrangement; whole-genome sequencing.