tetano
Editor, Senior Moderator
Clin Infect Dis
. 2021 Apr 24;ciab340.
doi: 10.1093/cid/ciab340. Online ahead of print.
Household exposure to SARS-CoV-2 and association with COVID-19 severity: a Danish nationwide cohort study
Marcella M Broccia[SUP] 1 2 [/SUP], Victoria Elizabeth V E de Knegt[SUP] 3 [/SUP], Elisabeth Helen Anna E H A Mills[SUP] 4 [/SUP], Amalie Lykkemark A L M?ller[SUP] 2 [/SUP], Filip F Gnesin[SUP] 2 [/SUP], Thea K T K Fischer[SUP] 5 [/SUP], Nertila N Zylyftari[SUP] 2 [/SUP], Stig Nikolaj S N Blomberg[SUP] 6 [/SUP], Mikkel Porsborg M P Andersen[SUP] 2 [/SUP], Morten M Schou[SUP] 7 [/SUP], Emil E Fosb?l[SUP] 8 [/SUP], Kristian K Kragholm[SUP] 7 9 [/SUP], Helle Collatz H C Christensen[SUP] 10 [/SUP], Laura Bech L B Polcwiartek[SUP] 11 [/SUP], Matthew M Phelps[SUP] 12 [/SUP], Lars L K?ber[SUP] 9 [/SUP], Christian C Torp-Pedersen[SUP] 2 4 [/SUP]
Affiliations
Abstract
Background: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of Coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.
Methods: We performed a Danish nationwide register-based cohort study including laboratory-confirmed SARS-CoV-2 infected individuals from 22 February to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having one individual tested positive for SARS-CoV-2 within the household. Cox proportional-hazards models were used to estimate the association between 'critical COVID-19' within and between households with and without secondary cases.
Results: From 15,063 multi-person households, 19,773 SARS-CoV-2 positive individuals were included; 11,632 were categorized as index cases without any secondary household cases, 3,431 as index cases with secondary cases, i.e. 22.8% of multi-person households, and 4,710 as secondary cases. 'Critical COVID-19' occurred in 2.9 % of index cases living with no secondary cases, 4.9 % of index cases with secondary cases, and 1.3 % of secondary cases. The adjusted hazard ratio for 'critical COVID-19' among index cases versus secondary cases within the same household was 2.50 (95%CI=1.88-3.34), 2.27 (95%CI=1.77-2.93) for index cases in households with no secondary cases versus secondary cases, and 1.1 (95%CI=0.93-1.30) for index cases with secondary cases versus index cases without secondary cases.
Conclusion: We found no increased hazard ratio of 'critical COVID-19' among household members of infected SARS-CoV-2 index cases.
Keywords: Corona; death; infectious dose; transmission; viral load.
. 2021 Apr 24;ciab340.
doi: 10.1093/cid/ciab340. Online ahead of print.
Household exposure to SARS-CoV-2 and association with COVID-19 severity: a Danish nationwide cohort study
Marcella M Broccia[SUP] 1 2 [/SUP], Victoria Elizabeth V E de Knegt[SUP] 3 [/SUP], Elisabeth Helen Anna E H A Mills[SUP] 4 [/SUP], Amalie Lykkemark A L M?ller[SUP] 2 [/SUP], Filip F Gnesin[SUP] 2 [/SUP], Thea K T K Fischer[SUP] 5 [/SUP], Nertila N Zylyftari[SUP] 2 [/SUP], Stig Nikolaj S N Blomberg[SUP] 6 [/SUP], Mikkel Porsborg M P Andersen[SUP] 2 [/SUP], Morten M Schou[SUP] 7 [/SUP], Emil E Fosb?l[SUP] 8 [/SUP], Kristian K Kragholm[SUP] 7 9 [/SUP], Helle Collatz H C Christensen[SUP] 10 [/SUP], Laura Bech L B Polcwiartek[SUP] 11 [/SUP], Matthew M Phelps[SUP] 12 [/SUP], Lars L K?ber[SUP] 9 [/SUP], Christian C Torp-Pedersen[SUP] 2 4 [/SUP]
Affiliations
- PMID: 33893489
- DOI: 10.1093/cid/ciab340
Abstract
Background: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of Coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.
Methods: We performed a Danish nationwide register-based cohort study including laboratory-confirmed SARS-CoV-2 infected individuals from 22 February to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having one individual tested positive for SARS-CoV-2 within the household. Cox proportional-hazards models were used to estimate the association between 'critical COVID-19' within and between households with and without secondary cases.
Results: From 15,063 multi-person households, 19,773 SARS-CoV-2 positive individuals were included; 11,632 were categorized as index cases without any secondary household cases, 3,431 as index cases with secondary cases, i.e. 22.8% of multi-person households, and 4,710 as secondary cases. 'Critical COVID-19' occurred in 2.9 % of index cases living with no secondary cases, 4.9 % of index cases with secondary cases, and 1.3 % of secondary cases. The adjusted hazard ratio for 'critical COVID-19' among index cases versus secondary cases within the same household was 2.50 (95%CI=1.88-3.34), 2.27 (95%CI=1.77-2.93) for index cases in households with no secondary cases versus secondary cases, and 1.1 (95%CI=0.93-1.30) for index cases with secondary cases versus index cases without secondary cases.
Conclusion: We found no increased hazard ratio of 'critical COVID-19' among household members of infected SARS-CoV-2 index cases.
Keywords: Corona; death; infectious dose; transmission; viral load.