tetano
Editor, Senior Moderator
Clin Nephrol Case Stud
. 2021 Apr 16;9:45-48.
doi: 10.5414/CNCS110219. eCollection 2021.
Influenza-associated hemolytic uremic syndrome: The pathogenic role of the virus
Valeria Silecchia[SUP] 1 [/SUP], Gianluca D'Onofrio[SUP] 2 [/SUP], Enrico Valerio[SUP] 3 [/SUP], Giulia Rubin[SUP] 3 [/SUP], Enrico Vidal[SUP] 4 [/SUP], Luisa Murer[SUP] 2 [/SUP]
Affiliations
Abstract
A 3-year-old girl came to our attention for fever and upper respiratory tract infection associated with thrombocytopenia, non-immune hemolytic anemia, and acute kidney injury (AKI). Complete blood count and renal function slowly normalized, with no need for dialysis. She was always normotensive with valid diuresis; her neurological status also rapidly improved. Nasal swab turned out positive for influenza A H1N1; stool test was negative for Shiga toxin-producing Escherichia coli (STEC). The patient was treated with oseltamivir for 5 days with a favorable outcome. Association between hemolytic uremic syndrome (HUS) and H1N1 influenza is poorly reported in literature [1, 2, 3, 4]. The pathogenic role of the virus in causing HUS is still controversial and debated [1, 2, 3, 4]. In our patient, complement activity markers (serum C3 and C5b-9) alteration suggested a transient, virus-mediated complement activation.
Keywords: H1N1; complement; hemolytic uremic syndrome; pathogenesis.
. 2021 Apr 16;9:45-48.
doi: 10.5414/CNCS110219. eCollection 2021.
Influenza-associated hemolytic uremic syndrome: The pathogenic role of the virus
Valeria Silecchia[SUP] 1 [/SUP], Gianluca D'Onofrio[SUP] 2 [/SUP], Enrico Valerio[SUP] 3 [/SUP], Giulia Rubin[SUP] 3 [/SUP], Enrico Vidal[SUP] 4 [/SUP], Luisa Murer[SUP] 2 [/SUP]
Affiliations
- PMID: 33884256
- PMCID: PMC8056317
- DOI: 10.5414/CNCS110219
Abstract
A 3-year-old girl came to our attention for fever and upper respiratory tract infection associated with thrombocytopenia, non-immune hemolytic anemia, and acute kidney injury (AKI). Complete blood count and renal function slowly normalized, with no need for dialysis. She was always normotensive with valid diuresis; her neurological status also rapidly improved. Nasal swab turned out positive for influenza A H1N1; stool test was negative for Shiga toxin-producing Escherichia coli (STEC). The patient was treated with oseltamivir for 5 days with a favorable outcome. Association between hemolytic uremic syndrome (HUS) and H1N1 influenza is poorly reported in literature [1, 2, 3, 4]. The pathogenic role of the virus in causing HUS is still controversial and debated [1, 2, 3, 4]. In our patient, complement activity markers (serum C3 and C5b-9) alteration suggested a transient, virus-mediated complement activation.
Keywords: H1N1; complement; hemolytic uremic syndrome; pathogenesis.