tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2016 Nov 26. pii: S1198-743X(16)30570-5. doi: 10.1016/j.cmi.2016.11.014. [Epub ahead of print]
[h=1]Clinical Characteristics and Outcome of Respiratory Syncytial Virus Infection among Adults Hospitalized with Influenza-like Illness in France.[/h] Loubet P[SUP]1[/SUP], Lenzi N[SUP]2[/SUP], Valette M[SUP]3[/SUP], Foulongne V[SUP]4[/SUP], Krivine A[SUP]5[/SUP], Houhou N[SUP]6[/SUP], Lagathu G[SUP]7[/SUP], Rogez S[SUP]8[/SUP], Alain S[SUP]9[/SUP], Duval X[SUP]10[/SUP], Galtier F[SUP]11[/SUP], Postil D[SUP]12[/SUP], Tattevin P[SUP]13[/SUP], Vanhems P[SUP]14[/SUP], Carrat F[SUP]15[/SUP], Lina B[SUP]16[/SUP], Launay O[SUP]17[/SUP]; FLUVAC Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] The aim of this study was to analyze characteristics and outcome of RSV infection in adults hospitalized with influenza-like illness (ILI).
[h=4]METHODS:[/h] Patients hospitalized with ILI were included in this prospective, multicenter study carried out in six French hospitals during three consecutive influenza seasons (2012-2015). RSV and other respiratory viruses were detected by multiplex PCR in nasopharyngeal swabs. Risk factors for RSV infection were identified by backward stepwise logistic regression analysis.
[h=4]RESULTS:[/h] A total of 1452 patients hospitalized with ILI were included, of whom 59% (861/1452) were older than 65 years and 83%(1211/1452) had underlying chronic illnesses. RSV was detected in 4% (59/1452), and influenza virus in 39%(566/1452). Risk factors for RSV infection were cancer (adjusted OR 2.1, 95%CI 1.1-4.1,p=0.04), and immunosuppressive treatment (aOR 2.0, 95%CI 1.1-3.8,p=0.03). Patients with RSV had a median length of stay of 9 days [6-25], and 57% of them (30/53) had complications, including pneumonia (23/53, 44%) and respiratory failure (15/53, 28%). Fifteen percent (8/53) were admitted to an ICU, and the in-hospital mortality rate was 8%(4/53). Pneumonia was more likely to occur in patients with RSV than in patients with RSV-negative ILI (44% (23/53) vs. 26% (362/1393),p=0.006) or with influenza virus infection (44% vs. 28% (157/560),p=0.02).
[h=4]CONCLUSION:[/h] RSV is an infrequent cause of ILI during periods of influenza virus circulation but can cause severe complications in hospitalized adults. Risk factors for RSV detection in adults hospitalized with ILI include cancer and immunosuppressive treatment. Specific immunization and antiviral therapy might benefit patients at risk.
Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Adults; Elderly; Influenza; Influenza-like Illness; Pneumonia; Respiratory Syncytial Virus
PMID: 27903461 DOI: 10.1016/j.cmi.2016.11.014
[PubMed - as supplied by publisher]
[h=1]Clinical Characteristics and Outcome of Respiratory Syncytial Virus Infection among Adults Hospitalized with Influenza-like Illness in France.[/h] Loubet P[SUP]1[/SUP], Lenzi N[SUP]2[/SUP], Valette M[SUP]3[/SUP], Foulongne V[SUP]4[/SUP], Krivine A[SUP]5[/SUP], Houhou N[SUP]6[/SUP], Lagathu G[SUP]7[/SUP], Rogez S[SUP]8[/SUP], Alain S[SUP]9[/SUP], Duval X[SUP]10[/SUP], Galtier F[SUP]11[/SUP], Postil D[SUP]12[/SUP], Tattevin P[SUP]13[/SUP], Vanhems P[SUP]14[/SUP], Carrat F[SUP]15[/SUP], Lina B[SUP]16[/SUP], Launay O[SUP]17[/SUP]; FLUVAC Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] The aim of this study was to analyze characteristics and outcome of RSV infection in adults hospitalized with influenza-like illness (ILI).
[h=4]METHODS:[/h] Patients hospitalized with ILI were included in this prospective, multicenter study carried out in six French hospitals during three consecutive influenza seasons (2012-2015). RSV and other respiratory viruses were detected by multiplex PCR in nasopharyngeal swabs. Risk factors for RSV infection were identified by backward stepwise logistic regression analysis.
[h=4]RESULTS:[/h] A total of 1452 patients hospitalized with ILI were included, of whom 59% (861/1452) were older than 65 years and 83%(1211/1452) had underlying chronic illnesses. RSV was detected in 4% (59/1452), and influenza virus in 39%(566/1452). Risk factors for RSV infection were cancer (adjusted OR 2.1, 95%CI 1.1-4.1,p=0.04), and immunosuppressive treatment (aOR 2.0, 95%CI 1.1-3.8,p=0.03). Patients with RSV had a median length of stay of 9 days [6-25], and 57% of them (30/53) had complications, including pneumonia (23/53, 44%) and respiratory failure (15/53, 28%). Fifteen percent (8/53) were admitted to an ICU, and the in-hospital mortality rate was 8%(4/53). Pneumonia was more likely to occur in patients with RSV than in patients with RSV-negative ILI (44% (23/53) vs. 26% (362/1393),p=0.006) or with influenza virus infection (44% vs. 28% (157/560),p=0.02).
[h=4]CONCLUSION:[/h] RSV is an infrequent cause of ILI during periods of influenza virus circulation but can cause severe complications in hospitalized adults. Risk factors for RSV detection in adults hospitalized with ILI include cancer and immunosuppressive treatment. Specific immunization and antiviral therapy might benefit patients at risk.
Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Adults; Elderly; Influenza; Influenza-like Illness; Pneumonia; Respiratory Syncytial Virus
PMID: 27903461 DOI: 10.1016/j.cmi.2016.11.014
[PubMed - as supplied by publisher]