Clinical efficacy observation of atomization inhalation combined with oral administration of oseltamivir in 4 cases with H7N9 avian influenza

[tetano]

Zhonghua Yi Xue Za Zhi. 2017 Jun 27;97(24):1883-1887. doi: 10.3760/cma.j.issn.0376-2491.2017.24.009.
[h=1][Clinical efficacy observation of atomization inhalation combined with oral administration of oseltamivir in 4 cases with H7N9 avian influenza].[/h] [Article in Chinese; Abstract available in Chinese from the publisher]
Li Z[SUP]1[/SUP], Fu XY, Fang XB, Li J, Chen T, Qiu LM, Cai J, Wang WL, Pan ZQ, Zhang Y, Zhou JL.
[h=3]Author information[/h]

[h=3]Abstract[/h] in English, Chinese
Objective: To investigate the clinical efficacy of atomization inhalation combined with oral administration of oseltamivir in treatment of human infection with H7N9 avian influenza. Methods: To analyze the clinical data of 4 patients hospitalized from Mar 6th 2017 to Apr 12th 2017 with avian influenza(H7N9) infection treated by conventional therapy(oseltamivir, 150 mg, po, Bid) plus with oseltamivir inhalation(75 mg dissolved in 20 ml N. S, Bid) and administered with antibacterial treatment, blood purification and immunomodulators. Results: Undergoing these comprehensive therapies, Bronchial lavage fluid and pharynx of 1 case was negative for H7N9 RNA after 24 h, 2 cases negative for H7N9 after 3 d and 1 case negative for H7N9 RNA after 4 d. All patients were cured and discharged without any complications. Conclusions: Aseltamivir inhalation combined with oral treatment can significantly shorten the time of virus nucleic acid turning negative, improve the efficacy of anti avian influenza virus H7N9, and increase the cure rate of avian influenza H7N9 infection patients.


[h=4]KEYWORDS:[/h] Atomization inhalation; Human infection with H7N9 avian influenza; Oseltamivir

PMID: 28648014