tetano
Editor, Senior Moderator
Int J Chron Obstruct Pulmon Dis. 2014;9:51-6. doi: 10.2147/COPD.S53590. Epub 2013 Dec 24.
Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease.
Nath KD1, Burel JG2, Shankar V3, Pritchard AL2, Towers M4, Looke D1, Davies JM2, Upham JW1.
Author information
Abstract
BACKGROUND AND OBJECTIVE:
Individuals with chronic obstructive pulmonary disease (COPD) are at a high risk of developing significant complications from infection with the influenza virus. It is therefore vital to ensure that prophylaxis with the influenza vaccine is effective in COPD. The aim of this study was to assess the immunogenicity of the 2010 trivalent influenza vaccine in persons with COPD compared to healthy subjects without lung disease, and to examine clinical factors associated with the serological response to the vaccine.
METHODS:
In this observational study, 34 subjects (20 COPD, 14 healthy) received the 2010 influenza vaccine. Antibody titers at baseline and 28 days post-vaccination were measured using the hemagglutination inhibition assay (HAI) assay. Primary endpoints included seroconversion (≥4-fold increase in antibody titers from baseline) and the fold increase in antibody titer after vaccination.
RESULTS:
Persons with COPD mounted a significantly lower humoral immune response to the influenza vaccine compared to healthy participants. Seroconversion occurred in 90% of healthy participants, but only in 43% of COPD patients (P=0.036). Increasing age and previous influenza vaccination were associated with lower antibody responses. Antibody titers did not vary significantly with cigarette smoking, presence of other comorbid diseases, or COPD severity.
CONCLUSION:
The humoral immune response to the 2010 influenza vaccine was lower in persons with COPD compared to non-COPD controls. The antibody response also declined with increasing age and in those with a history of prior vaccination.
KEYWORDS:
COPD, human influenza, humoral immunity, influenza vaccines, vaccination
PMID:
24399872
[PubMed - in process]
PMCID:
PMC3875241
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24399872
Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease.
Nath KD1, Burel JG2, Shankar V3, Pritchard AL2, Towers M4, Looke D1, Davies JM2, Upham JW1.
Author information
Abstract
BACKGROUND AND OBJECTIVE:
Individuals with chronic obstructive pulmonary disease (COPD) are at a high risk of developing significant complications from infection with the influenza virus. It is therefore vital to ensure that prophylaxis with the influenza vaccine is effective in COPD. The aim of this study was to assess the immunogenicity of the 2010 trivalent influenza vaccine in persons with COPD compared to healthy subjects without lung disease, and to examine clinical factors associated with the serological response to the vaccine.
METHODS:
In this observational study, 34 subjects (20 COPD, 14 healthy) received the 2010 influenza vaccine. Antibody titers at baseline and 28 days post-vaccination were measured using the hemagglutination inhibition assay (HAI) assay. Primary endpoints included seroconversion (≥4-fold increase in antibody titers from baseline) and the fold increase in antibody titer after vaccination.
RESULTS:
Persons with COPD mounted a significantly lower humoral immune response to the influenza vaccine compared to healthy participants. Seroconversion occurred in 90% of healthy participants, but only in 43% of COPD patients (P=0.036). Increasing age and previous influenza vaccination were associated with lower antibody responses. Antibody titers did not vary significantly with cigarette smoking, presence of other comorbid diseases, or COPD severity.
CONCLUSION:
The humoral immune response to the 2010 influenza vaccine was lower in persons with COPD compared to non-COPD controls. The antibody response also declined with increasing age and in those with a history of prior vaccination.
KEYWORDS:
COPD, human influenza, humoral immunity, influenza vaccines, vaccination
PMID:
24399872
[PubMed - in process]
PMCID:
PMC3875241
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24399872