tetano
Editor, Senior Moderator
Transpl Infect Dis. 2014 May 9. doi: 10.1111/tid.12228. [Epub ahead of print]
Clinical features and outcomes of influenza infections in lung transplant recipients: a single-season cohort study.
Schuurmans MM1, Isenring BD, Jungo C, Boeni J, Mueller NJ, Kohler M, Benden C.
Author information
Abstract
BACKGROUND:
For lung transplant recipients (LTRs) influenza infections pose a considerable risk for complications. These infections have mainly been described in hospitalized patients. The aim of this study was to describe characteristics of predominantly outpatient-treated influenza infections.
METHODS:
We conducted a single-season (2010/2011) retrospective observational study using database information of our cohort. Patients with evidence for respiratory tract infection received empirical oseltamivir and an oral antibiotic, pending results from nasopharyngeal swab analysis. In laboratory-confirmed influenza infection, treatment was continued and serial weekly swabs were performed until virologic results were negative.
RESULTS:
We identified 22 infections in 21 of 173 patients followed up; influenza A virus was diagnosed in 13 and influenza B virus in 9 infections. Leading presenting symptoms were cough and rhinorrhea. Oseltamivir was given within 48 h of symptom onset in 13 infections and within 72 h in 21 infections. Prolonged viral shedding (PVS) for ≥7 days was detected in 15 infections; median shedding duration for influenza A was 21 days. In univariable analysis, viral load (VL) at diagnosis was associated with extended duration of shedding (P = 0.006). Multivariable analysis confirmed this association. Bronchiolitis obliterans syndrome stage increased in 3 patients at 6-month follow-up.
CONCLUSION:
In this study, PVS of influenza virus was detected in the majority of LTRs and high VL at diagnosis was predictive for prolonged shedding, which occurred despite extended antiviral therapy.
? 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
infection, influenza, lung transplantation, outpatient, prolonged viral shedding, viral load
PMID:
24810480
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24810480
Clinical features and outcomes of influenza infections in lung transplant recipients: a single-season cohort study.
Schuurmans MM1, Isenring BD, Jungo C, Boeni J, Mueller NJ, Kohler M, Benden C.
Author information
Abstract
BACKGROUND:
For lung transplant recipients (LTRs) influenza infections pose a considerable risk for complications. These infections have mainly been described in hospitalized patients. The aim of this study was to describe characteristics of predominantly outpatient-treated influenza infections.
METHODS:
We conducted a single-season (2010/2011) retrospective observational study using database information of our cohort. Patients with evidence for respiratory tract infection received empirical oseltamivir and an oral antibiotic, pending results from nasopharyngeal swab analysis. In laboratory-confirmed influenza infection, treatment was continued and serial weekly swabs were performed until virologic results were negative.
RESULTS:
We identified 22 infections in 21 of 173 patients followed up; influenza A virus was diagnosed in 13 and influenza B virus in 9 infections. Leading presenting symptoms were cough and rhinorrhea. Oseltamivir was given within 48 h of symptom onset in 13 infections and within 72 h in 21 infections. Prolonged viral shedding (PVS) for ≥7 days was detected in 15 infections; median shedding duration for influenza A was 21 days. In univariable analysis, viral load (VL) at diagnosis was associated with extended duration of shedding (P = 0.006). Multivariable analysis confirmed this association. Bronchiolitis obliterans syndrome stage increased in 3 patients at 6-month follow-up.
CONCLUSION:
In this study, PVS of influenza virus was detected in the majority of LTRs and high VL at diagnosis was predictive for prolonged shedding, which occurred despite extended antiviral therapy.
? 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
infection, influenza, lung transplantation, outpatient, prolonged viral shedding, viral load
PMID:
24810480
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24810480