tetano
Editor, Senior Moderator
Clin Respir J. 2013 Dec 6. doi: 10.1111/crj.12087. [Epub ahead of print]
Clinical Features of 3 Avian Influenza H7N9 virus infected Patients in Shanghai.
Wang XF, Shi GC, Wan HY, Hang SG, Chen H, Chen W, Qu HP, Han BH, Zhou M.
Source
Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 200025, Shanghai, China.
Abstract
INTRODUCTION:
Since February 2013, a novel reassortant H7N9 virus associated with human deaths but no apparent outbreaks in poultry and wild birds has emerged in eastern China.
OBJECTIVES:
The potential reemergence of H7N9 during next year's influenza season demand a further understanding of this important disease.
METHODS:
Between March 1 to April 30, 2013, we obtained and analyzed clinical, epidemiologic, radiologic features and virologic data from 3 laboratory confirmed patients of A H7N9 infection admitted in Shanghai Ruijin Hospital.
RESULTS:
All patients were middle to old age (mean age 62 years) and overweight (mean body mass index 31) patients. 2 patients were exposed to poultry directly or indirectly in food market. They presented with fever and rapidly progressive pneumonia that did not respond to antibiotics. Time between onset of symptoms and onset of respiratory failure (days) were 7-11 days. 2 patients presented secondary invasive bacterial infections. All patients died on day 7 to day 86 after the onset of symptoms.
CONCLUSIONS:
Cross species poultry-to-person transmission of this new ressortant avian influenza H7N9 virus can result in severe and fatal respiratory disease like acute respiratory distress syndrome (ARDS) in humans. Reduplicate chest imaging examination is suggested for risky patients with fever and dyspnea. Secondary invasive bacterial infections and pneumothorax can cause severe and fatal consequence. Old age obesity and presence of comorbidity may be associated with increased mortality. Pulmonary fibrosis can be seen at late stage of the disease.
This article is protected by copyright. All rights reserved.
KEYWORDS:
A H7N9, ARDS, clinical features, fibrosis, secondary invasive bacterial infections
http://www.ncbi.nlm.nih.gov/pubmed/24308324
Clinical Features of 3 Avian Influenza H7N9 virus infected Patients in Shanghai.
Wang XF, Shi GC, Wan HY, Hang SG, Chen H, Chen W, Qu HP, Han BH, Zhou M.
Source
Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 200025, Shanghai, China.
Abstract
INTRODUCTION:
Since February 2013, a novel reassortant H7N9 virus associated with human deaths but no apparent outbreaks in poultry and wild birds has emerged in eastern China.
OBJECTIVES:
The potential reemergence of H7N9 during next year's influenza season demand a further understanding of this important disease.
METHODS:
Between March 1 to April 30, 2013, we obtained and analyzed clinical, epidemiologic, radiologic features and virologic data from 3 laboratory confirmed patients of A H7N9 infection admitted in Shanghai Ruijin Hospital.
RESULTS:
All patients were middle to old age (mean age 62 years) and overweight (mean body mass index 31) patients. 2 patients were exposed to poultry directly or indirectly in food market. They presented with fever and rapidly progressive pneumonia that did not respond to antibiotics. Time between onset of symptoms and onset of respiratory failure (days) were 7-11 days. 2 patients presented secondary invasive bacterial infections. All patients died on day 7 to day 86 after the onset of symptoms.
CONCLUSIONS:
Cross species poultry-to-person transmission of this new ressortant avian influenza H7N9 virus can result in severe and fatal respiratory disease like acute respiratory distress syndrome (ARDS) in humans. Reduplicate chest imaging examination is suggested for risky patients with fever and dyspnea. Secondary invasive bacterial infections and pneumothorax can cause severe and fatal consequence. Old age obesity and presence of comorbidity may be associated with increased mortality. Pulmonary fibrosis can be seen at late stage of the disease.
This article is protected by copyright. All rights reserved.
KEYWORDS:
A H7N9, ARDS, clinical features, fibrosis, secondary invasive bacterial infections
http://www.ncbi.nlm.nih.gov/pubmed/24308324