tetano
Editor, Senior Moderator
J Bras Nefrol. 2011 Jun;33(2):136-41.
[Clinical manifestations and evolution of infection by influenza A (H1N1) in kidney transplant recipients].
[Article in Portuguese]
Freitas TV, Ono G, Corr?a L, Gomes PS, Galante NZ, Tedesco-Silva H, Camargo LF, Medina-Pestana JO.
Source
Departamento de Medicina, Universidade Federal de S?o Paulo.
Abstract
INTRODUCTION:
The emergence of the pan>demic outbreak of influenza A (H1N1) in April, 2009, represented a logistic challenge for public health. Although most infected patients presented clinical and evolutionary manifestations which were very similar to seasonal influenza, a significant number of individuals developed pneumonia and severe acute respiratory failure. The impact of influenza A (H1N1) in immunocompromised patients is not well established yet.
METHODS:
This study aimed to analyze the clinical presentations and evolution of influenza A (H1N1) in 19 kidney transplant recipients. Influenza A (H1N1) infection was confirmed by RT-PCR in all patients. Treatment included antiviral therapy with oseltamivir phosphate and antibiotics.
RESULTS:
The studied population was compounded mostly of white people (63%), males (79%), at a mean age of 38.6 ? 17 years and patients with at least one comorbidity (53%). Influenza A (H1N1) infection was identified 41.6 ? 49.6 months after transplantation. Common symptoms included cough (100%), fever (84%), dyspnea (79%), and myalgia (42%). Acute allograft dysfunction was observed in 42% of the patients. Five patients (26%) were admitted to the Intensive Care Unit, two (10%) required invasive ventilation support, and two (10%) required vasoactive drugs. Mortality rate was 10%.
CONCLUSIONS:
Acute renal allograft dysfunction was a common finding. Clinical, laboratory, and evolutionary characteristics were comparable to those in the general population.
PMID:
21789426
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/21789426
[Clinical manifestations and evolution of infection by influenza A (H1N1) in kidney transplant recipients].
[Article in Portuguese]
Freitas TV, Ono G, Corr?a L, Gomes PS, Galante NZ, Tedesco-Silva H, Camargo LF, Medina-Pestana JO.
Source
Departamento de Medicina, Universidade Federal de S?o Paulo.
Abstract
INTRODUCTION:
The emergence of the pan>demic outbreak of influenza A (H1N1) in April, 2009, represented a logistic challenge for public health. Although most infected patients presented clinical and evolutionary manifestations which were very similar to seasonal influenza, a significant number of individuals developed pneumonia and severe acute respiratory failure. The impact of influenza A (H1N1) in immunocompromised patients is not well established yet.
METHODS:
This study aimed to analyze the clinical presentations and evolution of influenza A (H1N1) in 19 kidney transplant recipients. Influenza A (H1N1) infection was confirmed by RT-PCR in all patients. Treatment included antiviral therapy with oseltamivir phosphate and antibiotics.
RESULTS:
The studied population was compounded mostly of white people (63%), males (79%), at a mean age of 38.6 ? 17 years and patients with at least one comorbidity (53%). Influenza A (H1N1) infection was identified 41.6 ? 49.6 months after transplantation. Common symptoms included cough (100%), fever (84%), dyspnea (79%), and myalgia (42%). Acute allograft dysfunction was observed in 42% of the patients. Five patients (26%) were admitted to the Intensive Care Unit, two (10%) required invasive ventilation support, and two (10%) required vasoactive drugs. Mortality rate was 10%.
CONCLUSIONS:
Acute renal allograft dysfunction was a common finding. Clinical, laboratory, and evolutionary characteristics were comparable to those in the general population.
PMID:
21789426
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/21789426