tetano
Editor, Senior Moderator
Clinics (Sao Paulo)
. 2021 Nov 26;76:e3511.
doi: 10.6061/clinics/2021/e3511. eCollection 2021.
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
Thais T Fink[SUP] 1 [/SUP], Heloisa H S Marques[SUP] 1 [/SUP], Bruno Gualano[SUP] 1 [/SUP], Livia Lindoso[SUP] 1 [/SUP], Vera Bain[SUP] 1 [/SUP], Camilla Astley[SUP] 1 [/SUP], Fernanda Martins[SUP] 1 [/SUP], Denise Matheus[SUP] 1 [/SUP], Olivia M Matsuo[SUP] 1 [/SUP], Priscila Suguita[SUP] 1 [/SUP], Vitor Trindade[SUP] 1 [/SUP], Camila S Y Paula[SUP] 1 [/SUP], Sylvia C L Farhat[SUP] 1 [/SUP], Patricia Palmeira[SUP] 1 [/SUP], Gabriela N Leal[SUP] 1 [/SUP], Lisa Suzuki[SUP] 1 [/SUP], Vicente Odone Filho[SUP] 1 [/SUP], Magda Carneiro-Sampaio[SUP] 1 [/SUP], Alberto José S Duarte[SUP] 1 [/SUP], Leila Antonangelo[SUP] 1 [/SUP], Linamara R Batisttella[SUP] 1 [/SUP], Guilherme V Polanczyk[SUP] 1 [/SUP], Rosa Maria R Pereira[SUP] 1 [/SUP], Carlos Roberto R Carvalho[SUP] 1 [/SUP], Carlos A Buchpiguel[SUP] 1 [/SUP], Ana Claudia L Xavier[SUP] 1 [/SUP], Marilia Seelaender[SUP] 1 [/SUP], Clovis Artur Silva[SUP] 1 [/SUP], Maria Fernanda B Pereira[SUP] 1 [/SUP], HC-FMUSP Pediatric Post-COVID-19 Study Group; Adriana M E Sallum[SUP] 2 [/SUP], Alexandra V M Brentani[SUP] 2 [/SUP], Álvaro José S Neto[SUP] 2 [/SUP], Amanda Ihara[SUP] 2 [/SUP], Andrea R Santos[SUP] 2 [/SUP], Ana Pinheiro M Canton[SUP] 2 [/SUP], Andreia Watanabe[SUP] 2 [/SUP], Angélica C Dos Santos[SUP] 2 [/SUP], Antonio C Pastorino[SUP] 2 [/SUP], Bernadette D G M Franco[SUP] 2 [/SUP], Bruna Caruzo[SUP] 2 [/SUP], Carina Ceneviva[SUP] 2 [/SUP], Carolina C M F Martins[SUP] 2 [/SUP], Danilo Prado[SUP] 2 [/SUP], Deipara M Abellan[SUP] 2 [/SUP], Fabiana B Benatti[SUP] 2 [/SUP], Fabiana Smaria[SUP] 2 [/SUP], Fernanda T Gonçalves[SUP] 2 [/SUP], Fernando D Penteado[SUP] 2 [/SUP], Gabriela S F de Castro[SUP] 2 [/SUP], Guilherme S Gonçalves[SUP] 2 [/SUP], Hamilton Roschel[SUP] 2 [/SUP], Ilana R Disi[SUP] 2 [/SUP], Isabela G Marques[SUP] 2 [/SUP], Inar A Castro[SUP] 2 [/SUP], Izabel M Buscatti[SUP] 2 [/SUP], Jaline Z Faiad[SUP] 2 [/SUP], Jarlei Fiamoncini[SUP] 2 [/SUP], Joaquim C Rodrigues[SUP] 2 [/SUP], Jorge D A Carneiro[SUP] 2 [/SUP], Jose A Paz[SUP] 2 [/SUP], Juliana C Ferreira[SUP] 2 [/SUP], Juliana C O Ferreira[SUP] 2 [/SUP], Katia R Silva[SUP] 2 [/SUP], Karina L M Bastos[SUP] 2 [/SUP], Katia Kozu[SUP] 2 [/SUP], Lilian M Cristofani[SUP] 2 [/SUP], Lucas V B Souza[SUP] 2 [/SUP], Lucia M A Campos[SUP] 2 [/SUP], Luiz Vicente R F Silva Filho[SUP] 2 [/SUP], Marcelo T Sapienza[SUP] 2 [/SUP], Marcos S Lima[SUP] 2 [/SUP], Marlene P Garanito[SUP] 2 [/SUP], Márcia F A Santos[SUP] 2 [/SUP], Mayra B Dorna[SUP] 2 [/SUP], Nadia E Aikawa[SUP] 2 [/SUP], Nadia Litvinov[SUP] 2 [/SUP], Neusa K Sakita[SUP] 2 [/SUP], Paula V V Gaiolla[SUP] 2 [/SUP], Paula Pasqualucci[SUP] 2 [/SUP], Ricardo K Toma[SUP] 2 [/SUP], Simone Correa-Silva[SUP] 2 [/SUP], Sofia M Sieczkowska[SUP] 2 [/SUP], Marta Imamura[SUP] 2 [/SUP], Silvana Forsait[SUP] 2 [/SUP], Vera A Santos[SUP] 2 [/SUP], Yingying Zheng[SUP] 2 [/SUP]
Affiliations
Abstract
Objectives: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19).
Methods: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed.
Results: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls.
Conclusions: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.
. 2021 Nov 26;76:e3511.
doi: 10.6061/clinics/2021/e3511. eCollection 2021.
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
Thais T Fink[SUP] 1 [/SUP], Heloisa H S Marques[SUP] 1 [/SUP], Bruno Gualano[SUP] 1 [/SUP], Livia Lindoso[SUP] 1 [/SUP], Vera Bain[SUP] 1 [/SUP], Camilla Astley[SUP] 1 [/SUP], Fernanda Martins[SUP] 1 [/SUP], Denise Matheus[SUP] 1 [/SUP], Olivia M Matsuo[SUP] 1 [/SUP], Priscila Suguita[SUP] 1 [/SUP], Vitor Trindade[SUP] 1 [/SUP], Camila S Y Paula[SUP] 1 [/SUP], Sylvia C L Farhat[SUP] 1 [/SUP], Patricia Palmeira[SUP] 1 [/SUP], Gabriela N Leal[SUP] 1 [/SUP], Lisa Suzuki[SUP] 1 [/SUP], Vicente Odone Filho[SUP] 1 [/SUP], Magda Carneiro-Sampaio[SUP] 1 [/SUP], Alberto José S Duarte[SUP] 1 [/SUP], Leila Antonangelo[SUP] 1 [/SUP], Linamara R Batisttella[SUP] 1 [/SUP], Guilherme V Polanczyk[SUP] 1 [/SUP], Rosa Maria R Pereira[SUP] 1 [/SUP], Carlos Roberto R Carvalho[SUP] 1 [/SUP], Carlos A Buchpiguel[SUP] 1 [/SUP], Ana Claudia L Xavier[SUP] 1 [/SUP], Marilia Seelaender[SUP] 1 [/SUP], Clovis Artur Silva[SUP] 1 [/SUP], Maria Fernanda B Pereira[SUP] 1 [/SUP], HC-FMUSP Pediatric Post-COVID-19 Study Group; Adriana M E Sallum[SUP] 2 [/SUP], Alexandra V M Brentani[SUP] 2 [/SUP], Álvaro José S Neto[SUP] 2 [/SUP], Amanda Ihara[SUP] 2 [/SUP], Andrea R Santos[SUP] 2 [/SUP], Ana Pinheiro M Canton[SUP] 2 [/SUP], Andreia Watanabe[SUP] 2 [/SUP], Angélica C Dos Santos[SUP] 2 [/SUP], Antonio C Pastorino[SUP] 2 [/SUP], Bernadette D G M Franco[SUP] 2 [/SUP], Bruna Caruzo[SUP] 2 [/SUP], Carina Ceneviva[SUP] 2 [/SUP], Carolina C M F Martins[SUP] 2 [/SUP], Danilo Prado[SUP] 2 [/SUP], Deipara M Abellan[SUP] 2 [/SUP], Fabiana B Benatti[SUP] 2 [/SUP], Fabiana Smaria[SUP] 2 [/SUP], Fernanda T Gonçalves[SUP] 2 [/SUP], Fernando D Penteado[SUP] 2 [/SUP], Gabriela S F de Castro[SUP] 2 [/SUP], Guilherme S Gonçalves[SUP] 2 [/SUP], Hamilton Roschel[SUP] 2 [/SUP], Ilana R Disi[SUP] 2 [/SUP], Isabela G Marques[SUP] 2 [/SUP], Inar A Castro[SUP] 2 [/SUP], Izabel M Buscatti[SUP] 2 [/SUP], Jaline Z Faiad[SUP] 2 [/SUP], Jarlei Fiamoncini[SUP] 2 [/SUP], Joaquim C Rodrigues[SUP] 2 [/SUP], Jorge D A Carneiro[SUP] 2 [/SUP], Jose A Paz[SUP] 2 [/SUP], Juliana C Ferreira[SUP] 2 [/SUP], Juliana C O Ferreira[SUP] 2 [/SUP], Katia R Silva[SUP] 2 [/SUP], Karina L M Bastos[SUP] 2 [/SUP], Katia Kozu[SUP] 2 [/SUP], Lilian M Cristofani[SUP] 2 [/SUP], Lucas V B Souza[SUP] 2 [/SUP], Lucia M A Campos[SUP] 2 [/SUP], Luiz Vicente R F Silva Filho[SUP] 2 [/SUP], Marcelo T Sapienza[SUP] 2 [/SUP], Marcos S Lima[SUP] 2 [/SUP], Marlene P Garanito[SUP] 2 [/SUP], Márcia F A Santos[SUP] 2 [/SUP], Mayra B Dorna[SUP] 2 [/SUP], Nadia E Aikawa[SUP] 2 [/SUP], Nadia Litvinov[SUP] 2 [/SUP], Neusa K Sakita[SUP] 2 [/SUP], Paula V V Gaiolla[SUP] 2 [/SUP], Paula Pasqualucci[SUP] 2 [/SUP], Ricardo K Toma[SUP] 2 [/SUP], Simone Correa-Silva[SUP] 2 [/SUP], Sofia M Sieczkowska[SUP] 2 [/SUP], Marta Imamura[SUP] 2 [/SUP], Silvana Forsait[SUP] 2 [/SUP], Vera A Santos[SUP] 2 [/SUP], Yingying Zheng[SUP] 2 [/SUP]
Affiliations
- PMID: 34852145
- DOI: 10.6061/clinics/2021/e3511
Abstract
Objectives: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19).
Methods: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed.
Results: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls.
Conclusions: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.