tetano
Editor, Senior Moderator
Biochem Biophys Res Commun. 2014 Oct 14;453(4):821-825. doi: 10.1016/j.bbrc.2014.10.036. [Epub ahead of print]
Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding.
Liu G1, Xiang Y2, Guo C1, Pei Y2, Wang Y3, Kitazato K4.
Author information
Abstract
Influenza A virus (IAV) assembly and budding on host cell surface plasma membrane requires actin cytoskeleton reorganization. The underlying molecular mechanism involving actin reorganization remains unclarified. In this study, we found that the natural antiviral compound petagalloyl glucose (PGG) inhibits F-actin reorganization in the host cell membrane during the late stage of IAV infection, which are associated with the suppression of total cofilin-1 level and its phosphorylation. Knock-down of cofilin-1 reduces viral yields. These findings provide the first evidence that cofilin-1 plays an important role in regulating actin reorganization during IAV assembly and budding.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Cofilin-1; F-actin; Influenza A virus; Pentagalloyl glucose; Viral assembly; Viral budding
PMID:
25450354
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25450354
Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding.
Liu G1, Xiang Y2, Guo C1, Pei Y2, Wang Y3, Kitazato K4.
Author information
Abstract
Influenza A virus (IAV) assembly and budding on host cell surface plasma membrane requires actin cytoskeleton reorganization. The underlying molecular mechanism involving actin reorganization remains unclarified. In this study, we found that the natural antiviral compound petagalloyl glucose (PGG) inhibits F-actin reorganization in the host cell membrane during the late stage of IAV infection, which are associated with the suppression of total cofilin-1 level and its phosphorylation. Knock-down of cofilin-1 reduces viral yields. These findings provide the first evidence that cofilin-1 plays an important role in regulating actin reorganization during IAV assembly and budding.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Cofilin-1; F-actin; Influenza A virus; Pentagalloyl glucose; Viral assembly; Viral budding
PMID:
25450354
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25450354