tetano
Editor, Senior Moderator
Int J Infect Dis. 2017 May 5. pii: S1201-9712(17)30133-9. doi: 10.1016/j.ijid.2017.04.021. [Epub ahead of print]
[h=1]Combined Interventions for Mitigation of a Influenza A (H1N1) 2009 Outbreak in a Physical Training Camp in Beijing, China.[/h] Chu CY[SUP]1[/SUP], Silva UC[SUP]2[/SUP], Guo JP[SUP]3[/SUP], Wang Y[SUP]4[/SUP], Wen L[SUP]5[/SUP], Lee VJ[SUP]6[/SUP], Li SL[SUP]7[/SUP], Huang LY[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Many studies have suggested the effectiveness of single control measure in the containment and mitigation of pandemic (H1N1) 2009. We evaluate the effects of combined interventions by multiple control measures in reducing the impact of influenza A (H1N1) 2009 outbreak in the closed physical training camp in Beijing, China.
[h=4]METHODS:[/h] Oseltamivir was prescribed for the treatment of confirmed cases and possible cases and the prophylaxis of all other participants in this training. Public health control measures were also simultaneously applied, including isolation of patients and possible cases, personal protection and hygiene, social distancing measures. Symptom surveillance of all participants was initiated, and the actual attack rate was calculated. For comparison, the theoretical attack rate for this outbreak was projected by the Newton-Raphson numerical method.
[h=4]RESULTS:[/h] A total of 3256 participants were involved in this physical training. During this outbreak, 405 (68.3%) possible cases and 26 (4.4%) confirmed cases were reported before the intervention and completed oseltamivir treatment, and 162 (27.3%) possible cases were reported after the intervention and received part of treatment and part of prophylaxis, and the other 2663 participants completed oseltamivir prophylaxis. Of possible cases, 181 with fever ≥38.5?C were isolated. The actual attack rate for this outbreak of pandemic (H1N1) 2009 was 18.2%, which was rather lower than the theoretical attack rate of 80% projected.
[h=4]CONCLUSIONS:[/h] Combined interventions of large-scale antiviral ring prophylaxis and treatment and public health control measures could be applied to reduce the magnitude of 2009 H1N1 influenza outbreak in closed settings.
Copyright ? 2017. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] 2009 H1N1 Influenza; Intervention; Mitigation; Outbreak
PMID: 28483722 DOI: 10.1016/j.ijid.2017.04.021
[h=1]Combined Interventions for Mitigation of a Influenza A (H1N1) 2009 Outbreak in a Physical Training Camp in Beijing, China.[/h] Chu CY[SUP]1[/SUP], Silva UC[SUP]2[/SUP], Guo JP[SUP]3[/SUP], Wang Y[SUP]4[/SUP], Wen L[SUP]5[/SUP], Lee VJ[SUP]6[/SUP], Li SL[SUP]7[/SUP], Huang LY[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Many studies have suggested the effectiveness of single control measure in the containment and mitigation of pandemic (H1N1) 2009. We evaluate the effects of combined interventions by multiple control measures in reducing the impact of influenza A (H1N1) 2009 outbreak in the closed physical training camp in Beijing, China.
[h=4]METHODS:[/h] Oseltamivir was prescribed for the treatment of confirmed cases and possible cases and the prophylaxis of all other participants in this training. Public health control measures were also simultaneously applied, including isolation of patients and possible cases, personal protection and hygiene, social distancing measures. Symptom surveillance of all participants was initiated, and the actual attack rate was calculated. For comparison, the theoretical attack rate for this outbreak was projected by the Newton-Raphson numerical method.
[h=4]RESULTS:[/h] A total of 3256 participants were involved in this physical training. During this outbreak, 405 (68.3%) possible cases and 26 (4.4%) confirmed cases were reported before the intervention and completed oseltamivir treatment, and 162 (27.3%) possible cases were reported after the intervention and received part of treatment and part of prophylaxis, and the other 2663 participants completed oseltamivir prophylaxis. Of possible cases, 181 with fever ≥38.5?C were isolated. The actual attack rate for this outbreak of pandemic (H1N1) 2009 was 18.2%, which was rather lower than the theoretical attack rate of 80% projected.
[h=4]CONCLUSIONS:[/h] Combined interventions of large-scale antiviral ring prophylaxis and treatment and public health control measures could be applied to reduce the magnitude of 2009 H1N1 influenza outbreak in closed settings.
Copyright ? 2017. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] 2009 H1N1 Influenza; Intervention; Mitigation; Outbreak
PMID: 28483722 DOI: 10.1016/j.ijid.2017.04.021