tetano
Editor, Senior Moderator
Commun Biol
. 2023 Jul 24;6(1):772.
doi: 10.1038/s42003-023-05081-w. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5
Tomokazu Tamura[SUP] #[/SUP][SUP] 1 2 [/SUP], Daichi Yamasoba[SUP] #[/SUP][SUP] 3 4 [/SUP], Yoshitaka Oda[SUP] #[/SUP][SUP] 5 [/SUP], Jumpei Ito[SUP] #[/SUP][SUP] 3 [/SUP], Tomoko Kamasaki[SUP] #[/SUP][SUP] 6 7 8 [/SUP], Naganori Nao[SUP] #[/SUP][SUP] 2 9 10 [/SUP], Rina Hashimoto[SUP] #[/SUP][SUP] 11 [/SUP], Yoichiro Fujioka[SUP] 6 7 8 [/SUP], Rigel Suzuki[SUP] 1 2 [/SUP], Lei Wang[SUP] 5 12 [/SUP], Hayato Ito[SUP] 1 [/SUP], Yukie Kashima[SUP] 13 [/SUP], Izumi Kimura[SUP] 3 [/SUP], Mai Kishimoto[SUP] 14 [/SUP], Masumi Tsuda[SUP] 5 12 [/SUP], Hirofumi Sawa[SUP] 2 9 10 14 15 [/SUP], Kumiko Yoshimatsu[SUP] 16 [/SUP], Yuki Yamamoto[SUP] 17 [/SUP], Tetsuharu Nagamoto[SUP] 17 [/SUP], Jun Kanamune[SUP] 17 [/SUP], Yutaka Suzuki[SUP] 13 [/SUP], Yusuke Ohba[SUP] 6 7 8 [/SUP]; Genotype to Phenotype Japan (G2P-Japan) Consortium; Isao Yokota[SUP] 18 [/SUP], Keita Matsuno[SUP] 19 20 21 22 [/SUP], Kazuo Takayama[SUP] 23 24 [/SUP], Shinya Tanaka[SUP] 25 26 [/SUP], Kei Sato[SUP] 27 28 29 30 31 32 33 [/SUP], Takasuke Fukuhara[SUP] 34 35 36 37 [/SUP]
Collaborators, Affiliations
The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed BA.5 with the other Omicron variants BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2. Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. Furthermore, in our hamster model, in vivo pathogenicity of BA.5 was slightly higher than that of the other Omicron variants and less than that of ancestral B.1.1. Notably, BA.5 gains efficient virus spread compared with BA.1 and BA.2, leading to prompt immune responses. Our findings suggest that BA.5 has low pathogenicity compared with the ancestral strain but enhanced virus spread /inflammation compared with earlier Omicron subvariants.
. 2023 Jul 24;6(1):772.
doi: 10.1038/s42003-023-05081-w. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5
Tomokazu Tamura[SUP] #[/SUP][SUP] 1 2 [/SUP], Daichi Yamasoba[SUP] #[/SUP][SUP] 3 4 [/SUP], Yoshitaka Oda[SUP] #[/SUP][SUP] 5 [/SUP], Jumpei Ito[SUP] #[/SUP][SUP] 3 [/SUP], Tomoko Kamasaki[SUP] #[/SUP][SUP] 6 7 8 [/SUP], Naganori Nao[SUP] #[/SUP][SUP] 2 9 10 [/SUP], Rina Hashimoto[SUP] #[/SUP][SUP] 11 [/SUP], Yoichiro Fujioka[SUP] 6 7 8 [/SUP], Rigel Suzuki[SUP] 1 2 [/SUP], Lei Wang[SUP] 5 12 [/SUP], Hayato Ito[SUP] 1 [/SUP], Yukie Kashima[SUP] 13 [/SUP], Izumi Kimura[SUP] 3 [/SUP], Mai Kishimoto[SUP] 14 [/SUP], Masumi Tsuda[SUP] 5 12 [/SUP], Hirofumi Sawa[SUP] 2 9 10 14 15 [/SUP], Kumiko Yoshimatsu[SUP] 16 [/SUP], Yuki Yamamoto[SUP] 17 [/SUP], Tetsuharu Nagamoto[SUP] 17 [/SUP], Jun Kanamune[SUP] 17 [/SUP], Yutaka Suzuki[SUP] 13 [/SUP], Yusuke Ohba[SUP] 6 7 8 [/SUP]; Genotype to Phenotype Japan (G2P-Japan) Consortium; Isao Yokota[SUP] 18 [/SUP], Keita Matsuno[SUP] 19 20 21 22 [/SUP], Kazuo Takayama[SUP] 23 24 [/SUP], Shinya Tanaka[SUP] 25 26 [/SUP], Kei Sato[SUP] 27 28 29 30 31 32 33 [/SUP], Takasuke Fukuhara[SUP] 34 35 36 37 [/SUP]
Collaborators, Affiliations
- PMID: 37488344
- DOI: 10.1038/s42003-023-05081-w
The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed BA.5 with the other Omicron variants BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2. Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. Furthermore, in our hamster model, in vivo pathogenicity of BA.5 was slightly higher than that of the other Omicron variants and less than that of ancestral B.1.1. Notably, BA.5 gains efficient virus spread compared with BA.1 and BA.2, leading to prompt immune responses. Our findings suggest that BA.5 has low pathogenicity compared with the ancestral strain but enhanced virus spread /inflammation compared with earlier Omicron subvariants.