tetano
Editor, Senior Moderator
J Infect Dis. 2012 Jul 24. [Epub ahead of print]
Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period.
Mackay IM, Lambert SB, Faux CE, Arden KE, Nissen MD, Sloots TP, Nolan TM.
Source
Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, Sir Albert Sakzewski Virus Research Centre, Queensland Children's Health Services, University of Queensland, Queensland, Australia.
Abstract
Human rhinovirus (HRV) replication triggers exacerbation of asthma and causes most acute respiratory illnesses (ARIs) which may manifest as influenza-like illness. The recent addition of 60 previously unknown HRV-C viruses raised questions about the prevalence of these picornavirus species in the community, the extent of HRV diversity at a single site and whether the HRVs produce an equally diverse clinical impact in their hosts. We quantified HRV diversity and there was no clinical impact attributable to HRV species and genotypes among a community population of pre-school aged children who provided respiratory samples during ARIs in 2003. All HRV species were represented among 138 children with ARI and 74 distinct rhinovirus types co-circulated. Fever accompanied 32.8% of HRV-positive ARI cases. HRVs were less likely to be involved in a viral co-detection than DNA viruses suggesting virus interference at the community level, demonstrated by the inverse correlation between influenzavirus and HRV detection.
PMID:
22829638
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22829638
Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period.
Mackay IM, Lambert SB, Faux CE, Arden KE, Nissen MD, Sloots TP, Nolan TM.
Source
Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, Sir Albert Sakzewski Virus Research Centre, Queensland Children's Health Services, University of Queensland, Queensland, Australia.
Abstract
Human rhinovirus (HRV) replication triggers exacerbation of asthma and causes most acute respiratory illnesses (ARIs) which may manifest as influenza-like illness. The recent addition of 60 previously unknown HRV-C viruses raised questions about the prevalence of these picornavirus species in the community, the extent of HRV diversity at a single site and whether the HRVs produce an equally diverse clinical impact in their hosts. We quantified HRV diversity and there was no clinical impact attributable to HRV species and genotypes among a community population of pre-school aged children who provided respiratory samples during ARIs in 2003. All HRV species were represented among 138 children with ARI and 74 distinct rhinovirus types co-circulated. Fever accompanied 32.8% of HRV-positive ARI cases. HRVs were less likely to be involved in a viral co-detection than DNA viruses suggesting virus interference at the community level, demonstrated by the inverse correlation between influenzavirus and HRV detection.
PMID:
22829638
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22829638