tetano
Editor, Senior Moderator
J Virol Methods. 2012 Mar 13. [Epub ahead of print]
Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine.
Cheng LW, Huang SW, Huang LM, Chang LY, Shao PL, Kiang D, Wang JR.
Source
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan 701, Taiwan.
Abstract
Evaluation of the efficacy of influenza vaccines is essential for vaccine development. This study evaluated the neutralizing and hemagglutination-inhibition antibody response in subjects receiving the 2006-07 and 2007-08 seasonal influenza vaccines. ELISA-based microneutralization demonstrated a greater mean-fold increase and seroconversion rate than the hemagglutination-inhibition assay. The increase in the antibody titers against influenza H1 were higher than those against influenza H3 and influenza B, indicating that the H1 vaccine strain in the 2006-07 and 2007-08 seasons was more immunogenic. These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy.
Copyright © 2012 Elsevier B.V. All rights reserved.
PMID:
22433514
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22433514
Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine.
Cheng LW, Huang SW, Huang LM, Chang LY, Shao PL, Kiang D, Wang JR.
Source
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan 701, Taiwan.
Abstract
Evaluation of the efficacy of influenza vaccines is essential for vaccine development. This study evaluated the neutralizing and hemagglutination-inhibition antibody response in subjects receiving the 2006-07 and 2007-08 seasonal influenza vaccines. ELISA-based microneutralization demonstrated a greater mean-fold increase and seroconversion rate than the hemagglutination-inhibition assay. The increase in the antibody titers against influenza H1 were higher than those against influenza H3 and influenza B, indicating that the H1 vaccine strain in the 2006-07 and 2007-08 seasons was more immunogenic. These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy.
Copyright © 2012 Elsevier B.V. All rights reserved.
PMID:
22433514
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22433514