tetano
Editor, Senior Moderator
J Clin Microbiol. 2014 Jan 3. [Epub ahead of print]
Comparison of the BD Veritor? System Flu A+B with the Alere BinaxNOW(R) Influenza A & B Card for Detection of Influenza A and B in Respiratory Specimens from Pediatric Patients.
Hassan F, Nguyen A, Formanek A, Bell J, Selvarangan R.
Author information
Abstract
The performance characteristics of two commercially available rapid tests for influenza, the BD Veritor? System for Flu A+B (BD) and the Alere BinaxNOW? Influenza A & B Card (BN), were evaluated using 200 frozen clinical specimens collected during Jan 2011-June 2012 from pediatric patients. Real time RT-PCR was used as 'gold standard' to evaluate the results obtained by the two different assays. Of the 200 specimens tested, real-time RT-PCR assay detected Flu A or B virus in 116 samples, while BD detected 104 samples and BN detected 84 samples as positive. The overall sensitivity and specificity for detection of both influenza A and B virus in comparison to real-time RT-PCR was 89.6% (95% CI 82.2-94.3) and 98.8% (95% CI 92.6-99.9) for BD Veritor? and 72.4% (95% CI 63.2-80.0) and 100% (95% CI 94.5-100.0) for BinaxNOW?, respectively. Workflow analysis indicated that overall processing times for a batch size of 10 specimens were virtually identical between both systems. Overall, these results indicate that BD Veritor? assay was more sensitive than BinaxNOW? assay in detection of influenza A and B viruses in respiratory specimens from pediatric patients.
PMID:
24391198
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24391198
Comparison of the BD Veritor? System Flu A+B with the Alere BinaxNOW(R) Influenza A & B Card for Detection of Influenza A and B in Respiratory Specimens from Pediatric Patients.
Hassan F, Nguyen A, Formanek A, Bell J, Selvarangan R.
Author information
Abstract
The performance characteristics of two commercially available rapid tests for influenza, the BD Veritor? System for Flu A+B (BD) and the Alere BinaxNOW? Influenza A & B Card (BN), were evaluated using 200 frozen clinical specimens collected during Jan 2011-June 2012 from pediatric patients. Real time RT-PCR was used as 'gold standard' to evaluate the results obtained by the two different assays. Of the 200 specimens tested, real-time RT-PCR assay detected Flu A or B virus in 116 samples, while BD detected 104 samples and BN detected 84 samples as positive. The overall sensitivity and specificity for detection of both influenza A and B virus in comparison to real-time RT-PCR was 89.6% (95% CI 82.2-94.3) and 98.8% (95% CI 92.6-99.9) for BD Veritor? and 72.4% (95% CI 63.2-80.0) and 100% (95% CI 94.5-100.0) for BinaxNOW?, respectively. Workflow analysis indicated that overall processing times for a batch size of 10 specimens were virtually identical between both systems. Overall, these results indicate that BD Veritor? assay was more sensitive than BinaxNOW? assay in detection of influenza A and B viruses in respiratory specimens from pediatric patients.
PMID:
24391198
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24391198