Shiloh
Editor, Senior Moderator
Source: http://7thspace.com/headlines/34604...nship_to_viraemia_and_antibody_responses.html
Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses
Dengue is a major public health problem in tropical and subtropical countries. Rapid and easy diagnosis of dengue can assist patient triage and care-management.
The detection of DENV NS1 on rapid lateral flow tests offers a fast route to a presumptive dengue diagnosis but careful evaluations are urgently needed as more and more people use them.MethodSThe sensitivity and specificity of the Bio-Rad NS1 Ag Strip and SD Dengue Duo (NS1/IgM/IgG) lateral flow rapid tests were evaluated in a panel of plasma samples from 245 Vietnamese patients with RT-PCR confirmed dengue and 47 with other febrile illnesses...
...Conclusions: These data suggest that the NS1 test component of these assays are highly specific and have similar levels of sensitivity.
The IgM parameter in the SD Duo test improved overall test sensitivity without compromising specificity. The SD Dengue Duo lateral flow rapid test deserves further prospective evaluation in dengue endemic settings.
Author: Vianney TricouHang VuNhu QuynhChau NguyenHien TranJeremy FarrarBridget WillsCameron Simmons
Credits/Source: BMC Infectious Diseases 2010, 10:142
Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses
Dengue is a major public health problem in tropical and subtropical countries. Rapid and easy diagnosis of dengue can assist patient triage and care-management.
The detection of DENV NS1 on rapid lateral flow tests offers a fast route to a presumptive dengue diagnosis but careful evaluations are urgently needed as more and more people use them.MethodSThe sensitivity and specificity of the Bio-Rad NS1 Ag Strip and SD Dengue Duo (NS1/IgM/IgG) lateral flow rapid tests were evaluated in a panel of plasma samples from 245 Vietnamese patients with RT-PCR confirmed dengue and 47 with other febrile illnesses...
...Conclusions: These data suggest that the NS1 test component of these assays are highly specific and have similar levels of sensitivity.
The IgM parameter in the SD Duo test improved overall test sensitivity without compromising specificity. The SD Dengue Duo lateral flow rapid test deserves further prospective evaluation in dengue endemic settings.
Author: Vianney TricouHang VuNhu QuynhChau NguyenHien TranJeremy FarrarBridget WillsCameron Simmons
Credits/Source: BMC Infectious Diseases 2010, 10:142